Viagra cost

AdvertisementContinue reading the main storySupported byContinue reading the main storyPhys EdWhat Scientists Are Learning About Estrogen and ExerciseA study in mice raises intriguing questions about the ways that hormones influence the brain viagra cost and motivate the body to move.Credit...Getty ImagesOct. 20, 2021, viagra cost 12:42 p.m. ETEstrogen may change brain activity in ways that could affect how physically active we are, according to a remarkable new study in mice that looked at DNA, hormones and brain cells.

Using advanced technology to pinpoint and reprogram specific genes and neurons in living animals, the study found that surges of estrogen jump-started processes in the mouse brain that prompted the animals — even males — to become more active.The study, which was published recently viagra cost in Nature, involved mice. While humans share many of the same relevant hormones, genes and neurons, we are not mice and cannot yet say whether our brains and physiological systems work the same way. But the findings may open intriguing avenues of inquiry into why women so often become inactive after viagra cost menopause, when estrogen fades.

The results also underscore how the brain and internal biological processes work together to play an unexpected and substantial role in whether the body gets up and moves or remains mostly still.Moving and matingFor close to a century, since a famous 1924 study involving rats, scientists have known that female mammals tend to be most physically active just before they ovulate, when they are also most sexually receptive viagra cost. This behavior makes evolutionary sense, since female animals presumably need to be on the hunt then for a mate. In the intervening decades, researchers began to speculate that estrogen must play a driving role in viagra cost this behavior, with subsequent studies indicating that female lab animals’ daily skitterings typically would surge and wane in tandem with their estrogen levels.

But how could estrogen, which primarily controls ovulation and other aspects of reproduction, influence physical activity?. That physiological puzzle recently drew the attention of Holly Ingraham, the Herzstein Endowed Professor of Physiology at the University of California, San Francisco, who has viagra cost a longstanding research interest in women’s physiology and metabolism. She and her collaborators wondered if estrogen might somehow shape genetic activity in the brain, which would then activate brain cells in ways that could set in motion, well, motion itself.To investigate that possibility, the scientists first gathered a crowd of healthy adult female mice and chemically blocked estrogen uptake in some of them, while tracking how much all of the animals moved.

Almost immediately, the animals without estrogen became noticeably more sedentary than the other females, confirming that estrogen somehow affects physical activity.Finding the movement cellsNext, the researchers examined the activity of a number of genes in the animals’ brains, noting that one, in particular, enthusiastically pumped out extra proteins when the animals’ brains were bathed in estrogen but became viagra cost almost quiet when estrogen was absent. This gene, viagra cost melanocortin-4, or Mc4r, previously had been linked in people to food intake and regulation of body weight. But the scientists now guessed it might also be the bridge between estrogen and the impulse to be physically active, an idea they substantiated by using high-tech genetic mapping techniques refined by one of the study’s authors, Jessica Tollkuhn, an assistant professor at Cold Spring Harbor Laboratory School of Biological Sciences in Cold Spring Harbor, N.Y.These techniques showed, in real time, estrogen binding to Mc4r genes in certain neurons, especially those in a part of the mouse brain involved in energy expenditure.

These brain cells also shared connections with other viagra cost neurons elsewhere in the brain that control the speed at which animals move. Taken together, this experiment showed estrogen firing up a particular gene that turns on certain brain cells that then should be expected to nudge an animal to move.But the scientists had not yet seen these genes and neurons in action, so, as a final aspect of the study, they used a sophisticated technique known as chemogenetics to directly galvanize the relevant neurons in female mice that had been bred to produce no estrogen. Once physically sluggish, these mice now explored, stood, played and ran far more than they had before.Similarly, when the scientists used a form of the viagra cost gene-editing technology CRISPR to gin up activity of the Mc4r gene in female animals’ brains, the mice became almost twice as active as before, a physical surge that persisted for weeks.

Even male mice viagra cost moved more when their Mc4r gene activity was dialed up by CRISPR, although not as much as the peripatetic females.These results highlight the “complexity of physical activity behavior,” Dr. Ingraham said, and how the willingness to spontaneously move — or not — for any animal likely involves an intricate interplay between genetics, endocrinology and neurology, along with conscious deliberation.The study also raises the intriguing possibility that the “timing of exercise, to have its most beneficial impact for women, might be fine-tuned by considering the changing hormonal milieu,” including the hormonal changes of menopause, said Dr. Tamas Horvath, a professor of neuroscience and obstetrics, gynecology and reproductive sciences at the viagra cost Yale School of Medicine and chairman of the school’s department of comparative medicine.

€œOf course, all these observations in mice need to be confirmed to operate in us, humans,” said Dr. Horvath, who was not viagra cost involved in the current research. €œHowever, the fact that this mechanism is found in an ancient part of the brain suggests that it will be applicable for most mammals, including humans.”‘Knowledge is power’Dr.

Ingraham agreed viagra cost. €œWe assume this circuit is working in humans, too,” she said and, if so, the new study and any subsequent, related research could help to explain, in part, why inactivity is so common in women after menopause and also offer some potential strategies for overcoming viagra cost the pull toward lassitude. Increasing estrogen levels in older women, for instance, might, in theory, encourage more movement, though estrogen replacement therapy remains a complicated subject because of heightened cancer risks and other health concerns.

The study does hint, however, that it could, eventually, be possible to bypass estrogen and recreate its effects with new therapies that would directly target the Mc4r gene or the relevant viagra cost neurons in people’s brains and mimic the effects of estrogen without the hormone itself. Any such medical advances are years in the future, Dr. Ingraham said.Already, though, by delving into viagra cost “the interrelationship between hormones and physical activity in females, this study has significant implications for human research studying the menstrual cycle and hormonal contraceptives and also menopause,” said Paul Ansdel, a lecturer in exercise physiology at Northumbria University in England, who was not involved with the study but has extensively studied menstruation and physical performance.

€œWe know the importance of exercising in later life for promoting and maintaining health,” he continued, “so the challenge for us now is to understand the best ways to stay active throughout the major hormonal transition that is menopause.”“Knowledge is power,” Dr. Ingraham concluded viagra cost. She noted that because so many of us are living longer now, better understanding of viagra cost why — and whether — we choose to move can help make those years healthier.

For example, knowing that biology might angle us toward the couch if we are women and aging, we could use fitness trackers or training diaries to help us compare our activities from year to year. Or, just honestly assess whether viagra cost we are as active now as we would like to be, whatever our age (or gender). The brain is a complex organ and our motivations for exercise varied and deep, but we always have the option “to decide to be active,” Dr.

Ingraham said, to make the viagra cost choice to get up and move.AdvertisementContinue reading the main story#masthead-section-label, #masthead-bar-one { display. None }The erectile dysfunction viagraerectile dysfunction treatment Updateserectile dysfunction Map and CasesWorld Vaccination Trackertreatment FAQCredit...Aileen Son for The New York TimesSkip to contentSkip viagra cost to site indexAsk WellShould You Get a erectile dysfunction treatment Booster if You Are Pregnant?. Experts strongly agree that the shots benefit the mother as well as the fetus.Credit...Aileen Son for The New York TimesSupported byContinue reading the main storyOct.

19, 2021Last viagra cost December, I cried into my mask on the subway home after getting the only holiday gift I wanted. The Pfizer treatment. As a gastroenterologist viagra cost treating hospitalized erectile dysfunction treatment patients, it brought back a flood of difficult memories from the past year.

Among the most haunting were the pregnant people with severe liver injury I cared for in the intensive care unit who couldn’t see their newborns.Two months later, I became pregnant myself.The viagra has transformed pregnancy, an already stressful life event, into a unique minefield. Pregnant people faced early bans on hospital visitors during labor, exclusion from the original vaccination studies and disproportionate devastation from the Delta variant, which in August cost 22 lives — the highest number of erectile dysfunction treatment deaths in a single month viagra cost among pregnant people since the viagra started.Since January 2020, at least 180 pregnant people have died from erectile dysfunction treatment. The recent pleas from federal health officials for all pregnant people to viagra cost get vaccinated as soon as possible has provided the kind of no-nonsense clarity that expecting parents might have been waiting for.

But what does that mean for boosters?. The Centers for Disease Control and Prevention lists pregnancy as a medical condition that would make someone eligible for viagra cost a erectile dysfunction treatment booster. Official guidelines firmly declare that you “should” get a booster if you meet certain criteria — for instance if you work in a high-exposure field, like as a nurse or teacher (both professions that incidentally make up the two most common occupations for pregnant workers in the United States).

But the guidelines viagra cost recommend that people who fall into other high risk categories, including those who are pregnant, weigh the individual risks and benefits of the booster.This can leave many pregnant people like myself wondering if they should rush to get a third shot. Dr. Dana Meaney-Delman, the lead scientist for maternal erectile dysfunction treatment immunization at the C.D.C., has been viagra cost considering these questions carefully.

€œThere’s nothing to suggest boosters are a safety issue viagra cost. We have great confidence in these treatments,” she said, adding that anyone who is pregnant, postpartum, considering pregnancy or who might be pregnant in the future should get the treatment. €œThat’s the most urgent message,” she said.She noted that, as an OB-GYN herself, she encourages a third dose for her viagra cost pregnant patients.

€œFrom a biological plausibility perspective, there’s really no reason not to recommend a booster,” she said.The American College of Obstetricians and Gynecologists, as well as the Society for Maternal-Fetal Medicine, also did not mince words in the advisories they updated on Oct. 1. Yes, pregnant people who completed the Pfizer-BioNTech treatment series at least six months ago should get the booster shot.

(Other treatments will likely soon be authorized as boosters.)Their recommendations underscore the risks of severe consequences from erectile dysfunction treatment during pregnancy, as well as evidence of waning immunity.Many experts suggest that pregnant people are not so much immunocompromised, as once believed, but that their immune systems change in unique ways during each stage of pregnancy, opening windows of vulnerability to erectile dysfunction treatment. Besides these changes, the physical demands of pregnancy — the growing fetus’ strain on the diaphragm and lungs, the increased strain on the cardiovascular system — put pregnant people at higher risk of being hospitalized and dying from erectile dysfunction treatment without the treatment.Signing up for a booster shot might also help the unborn baby. Dr.

Andrea Edlow, an OB-GYN and researcher at Massachusetts General Hospital, demonstrated that the immune response induced by erectile dysfunction treatment mRNA treatments in pregnant and lactating women was far greater than the response produced by a erectile dysfunction . They also found that those antibodies were robustly passed to the fetus through the placenta, as well as through breast milk.The erectile dysfunction viagra. Latest UpdatesUpdated Oct.

20, 2021, 6:26 p.m. ETNew viagra cases are rising on some Caribbean islands, the W.H.O. Says.Brazilian Senators back off genocide and homicide charges for Bolsonaro.The F.D.A.

Authorizes Moderna and J.&J. Boosters and allows a mix-and-match booster strategy.Although countries like Israel and most recently the United States have started giving booster shots to pregnant people, experts are still collecting data on their outcomes. It might be months, or more, before we have more information.Nonetheless, there is no reason to expect that the booster side effects in pregnant people will be different than those in the general population, according to Dr.

Meaney-Delman, who led a C.D.C. Study on vaccinations in pregnancy.The study, which analyzed the self-reported side effects from more than 35,000 pregnant people, demonstrated that treatment reactions were similar among pregnant women compared with nonpregnant women. Among the most common were pain at the injection site and fatigue..css-1kpebx{margin:0 #NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-family:nyt-cheltenham,georgia,'times new roman',times,serif;font-weight:700;font-size:1.375rem;line-height:1.625rem;}@media (min-width:740px){#NYT_BELOW_MAIN_CONTENT_REGION .css-1kpebx{font-size:1.6875rem;line-height:1.875rem;}}@media (min-width:740px){.css-1kpebx{font-size:1.25rem;line-height:1.4375rem;}}.css-1gtxqqv{margin-bottom:0;}.css-k59gj9{display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-flex-direction:column;-ms-flex-direction:column;flex-direction:column;width:100%;}.css-1e2usoh{font-family:inherit;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-webkit-justify-content:space-between;-ms-flex-pack:justify;justify-content:space-between;border-top:1px solid #ccc;padding:10px 0px 10px 0px;background-color:#fff;}.css-1jz6h6z{font-family:inherit;font-weight:bold;font-size:1rem;line-height:1.5rem;text-align:left;}.css-1t412wb{box-sizing:border-box;margin:8px 15px 0px 15px;cursor:pointer;}.css-hhzar2{-webkit-transition:-webkit-transform ease 0.5s;-webkit-transition:transform ease 0.5s;transition:transform ease 0.5s;}.css-t54hv4{-webkit-transform:rotate(180deg);-ms-transform:rotate(180deg);transform:rotate(180deg);}.css-1r2j9qz{-webkit-transform:rotate(0deg);-ms-transform:rotate(0deg);transform:rotate(0deg);}.css-e1ipqs{font-size:1rem;line-height:1.5rem;padding:0px 30px 0px 0px;}.css-e1ipqs a{color:#326891;-webkit-text-decoration:underline;text-decoration:underline;}.css-e1ipqs a:hover{-webkit-text-decoration:none;text-decoration:none;}.css-1o76pdf{visibility:show;height:100%;padding-bottom:20px;}.css-1sw9s96{visibility:hidden;height:0px;}.css-1in8jot{background-color:white;border:1px solid #e2e2e2;width:calc(100% - 40px);max-width:600px;margin:1.5rem auto 1.9rem;padding:15px;box-sizing:border-box;font-family:'nyt-franklin',arial,helvetica,sans-serif;text-align:left;}@media (min-width:740px){.css-1in8jot{padding:20px;width:100%;}}.css-1in8jot:focus{outline:1px solid #e2e2e2;}#NYT_BELOW_MAIN_CONTENT_REGION .css-1in8jot{border:none;padding:10px 0 0;border-top:2px solid #121212;}What to Know About erectile dysfunction treatment Booster ShotsThe F.D.A.

Has authorized booster shots for millions of recipients of the Pfizer-BioNTech, Moderna and Johnson &. Johnson treatments. Pfizer and Moderna recipients who are eligible for a booster include people 65 and older, and younger adults at high risk of severe erectile dysfunction treatment because of medical conditions or where they work.

Eligible Pfizer and Moderna recipients can get a booster at least six months after their second dose. All Johnson &. Johnson recipients will be eligible for a second shot at least two months after the first.Yes.

The F.D.A. Has updated its authorizations to allow medical providers to boost people with a different treatment than the one they initially received, a strategy known as “mix and match.” Whether you received Moderna, Johnson &. Johnson or Pfizer-BioNTech, you may receive a booster of any other treatment.

Regulators have not recommended any one treatment over another as a booster. They have also remained silent on whether it is preferable to stick with the same treatment when possible.The C.D.C. Has said the conditions that qualify a person for a booster shot include.

Hypertension and heart disease. Diabetes or obesity. Cancer or blood disorders.

Weakened immune system. Chronic lung, kidney or liver disease. Dementia and certain disabilities.

Pregnant women and current and former smokers are also eligible.The F.D.A. Authorized boosters for workers whose jobs put them at high risk of exposure to potentially infectious people. The C.D.C.

Says that group includes. Emergency medical workers. Education workers.

Food and agriculture workers. Manufacturing workers. Corrections workers.

U.S. Postal Service workers. Public transit workers.

Grocery store workers.Yes. The C.D.C. Says the erectile dysfunction treatment may be administered without regard to the timing of other treatments, and many pharmacy sites are allowing people to schedule a flu shot at the same time as a booster dose.Regarding timing, the sooner you get a booster during your pregnancy, the better, Dr.

Edlow said. Not only does an earlier booster likely mean a lower chance of a breakthrough (which could increase the risk of preterm birth), but, as is the case with other recommended treatments in pregnancy, an earlier shot could translate to more antibodies passed to the fetus.Waiting until just before delivery means you will have lower antibody levels, “and you don’t have as much time for the antibodies to transfer across the cord, so it’s just less effective,” Dr. Edlow said.

€œYou’re going to give your baby the best protection if you do it earlier.”Another reason eligible pregnant people shouldn’t wait to get a booster is that the types of antibodies that pass through the umbilical cord are different from those that pass through breast milk. The blood-borne antibodies that cross the umbilical cord are much longer lasting than those primarily passed through breast milk, Dr. Edlow said.

By getting the booster during pregnancy, the baby gets the benefit of both.In the end, I decided to receive the booster shot two weeks ago at 33 weeks pregnant. I had some fatigue (and took a nap in the evening) as well as muscle aches the next day. By the following morning, I felt completely back to normal.“You shouldn’t think, ‘I need to get boosted or I’m going to die from erectile dysfunction treatment.’ That’s the rationale for the first treatment doses,” Dr.

Edlow said. The booster, however, can prevent pregnant people from symptomatic illness or from transferring the viagra to young children at home in addition to providing protection to their newborns.“I don’t think there are any special considerations. I think they should just go get the booster,” she said.Dr.

Trisha Pasricha is a writer and physician at Massachusetts General Hospital. Her work has appeared in the Washington Post, the Los Angeles Times and The Atlantic.AdvertisementContinue reading the main story.

Can i take viagra every day

Viagra
Avana
Vidalista
Tadalista super active
Valif
Forzest
Can cause heart attack
Twice a day
Once a day
Once a day
Twice a day
Once a day
Twice a day
Best price for generic
50mg 270 tablet $242.95
100mg 60 tablet $399.95
40mg 20 tablet $54.95
20mg 60 softgel capsule $239.95
20mg 30 tablet $119.95
20mg 12 tablet $99.95
Best price
150mg 90 tablet $242.95
50mg 60 tablet $234.95
60mg 60 tablet $149.95
20mg 60 softgel capsule $239.95
20mg 20 tablet $89.95
20mg 60 tablet $399.95
Long term side effects
Ask your Doctor
Yes
You need consultation
Ask your Doctor
No
Ask your Doctor
Dosage
22h
12h
18h
2h
20h
15h
Free pills
25mg
Consultation
Ask your Doctor
Consultation
20mg
Consultation
Can women take
No
Online
No
No
Online
Online

Abemaciclib 215268 viagra price Verzenio Eli can i take viagra every day Lilly Canada Inc. N/A 2019-04-08 2025-04-08 N/A 2027-04-08 acalabrutinib 214504 Calquence AstraZeneca Canada Inc. N/A 2019-08-23 2025-08-23 N/A 2027-08-23 albiglutide can i take viagra every day 165145 Eperzan GlaxoSmithKline Inc.

N/A 2015-07-15 2021-07-15 N/A 2023-07-15 alectinib hydrochloride 189442 Alecensaro Hoffmann-La Roche Limited N/A 2016-09-29 2022-09-29 N/A 2024-09-29 alirocumab 183116 Praluent Sanofi-aventis Canada Inc. N/A 2016-04-11 2022-04-11 N/A 2024-04-11 alogliptin benzoate 158335 Nesina Takeda Canada Inc. KazanoOseni 2013-11-27 2019-11-27 N/A can i take viagra every day 2021-11-27 alpelisib 226941 Piqray Novartis Pharmaceuticals Canada Inc.

N/A 2020-03-11 2026-03-11 N/A 2028-03-11 amifampridine (supplied as amifampridine phosphate) 232685 Firdapse Kye Pharmaceuticals Inc. N/A 2020-07-31 2026-07-31 N/A 2028-07-31 anthrax immune globulin (human) 200446 Anthrasil Emergent BioSolutions Canada Inc. N/A 2017-11-06 2023-11-06 Yes 2026-05-06 antihemophilic factor can i take viagra every day (recombinant BDD), Fc fusion protein 163447 Eloctate Sanofi-Aventis Canada Inc.

N/A 2014-08-22 2020-08-22 Yes 2023-02-22 antihemophilic factor (recombinant), pegylated 189709 Adynovate Takeda Canada Inc. N/A 2016-11-17 2022-11-17 Yes 2025-05-17 antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) 210935 Jivi Bayer Inc. N/A 2018-10-18 2024-10-18 Yes 2027-04-18 antihemophilic factor (recombinant, can i take viagra every day B-domain deleted) (also known as simoctocog alfa) 169551 Nuwiq Octapharma Pharmazeutika Produktionsges.m.b.H N/A 2014-10-23 2020-10-23 Yes 2023-04-23 antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) 190891 Afstyla CSL Behring Canada Inc.

N/A 2016-12-12 2022-12-12 Yes 2025-06-12 anthrax antigen fiate 212387 Biothrax Emergent Biodefense Operations Lansing LLC N/A 2018-12-13 2024-12-13 N/A 2026-12-13 antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) 218531 Esperoct Novo Nordisk Canada Inc. N/A 2019-07-04 2025-07-04 Yes 2028-01-04 apalutamide 211942 Erleada Janssen Inc. N/A 2018-07-03 2024-07-03 can i take viagra every day N/A 2026-07-03 apremilast 169862 Otezla Amgen Canada Inc.

N/A 2014-11-12 2020-11-12 N/A 2022-11-12 asfotase alfa 179340 Strensiq Alexion Pharma International Sàrl N/A 2015-08-14 2021-08-14 Yes 2024-02-14 asunaprevir 172617 Sunvepra Bristol-Myers Squibb Canada N/A 2016-03-09 2022-03-09 N/A 2024-03-09 atezolizumab 196843 Tecentriq Hoffmann-La Roche Limited N/A 2017-04-12 2023-04-12 Yes 2025-10-12 avalglucosidase alfa 245680 Nexviazyme Sanofi-Aventis Canada Inc. N/A 2021-11-12 2027-11-12 Yes 2030-05-12 avelumab 204052 Bavencio EMD Serono, a Division of EMD Inc., Canada N/A 2017-12-18 2023-12-18 N/A 2025-12-18 axicabtagene ciloleucel 218389 Yescarta Gilead Sciences Canada Inc N/A 2019-02-13 2025-02-13 N/A 2027-02-13 azelastine hydrochloride 169604 Dymista Meda Pharmaceuticals Ltd. N/A 2014-10-23 can i take viagra every day 2020-10-23 Yes 2023-04-23 baloxavir marboxil 227361 Xofluza Hoffmann-La Roche Limited N/A 2020-02-19 2026-02-19 Yes 2028-08-19 baricitinib 193687 Olumiant Eli Lilly Canada Inc.

N/A 2018-08-17 2024-08-17 N/A 2026-08-17 bazedoxifene acetate 160681 Duavive Pfizer Canada Inc. N/A 2014-10-23 2020-10-23 N/A 2022-10-23 benralizumab 204008 Fasenra AstraZeneca Canada Inc. N/A 2018-02-22 2024-02-22 Yes can i take viagra every day 2026-08-22 bepotastine besilate 179294 Bepreve Bausch and Lomb Incorporated N/A 2016-07-27 2022-07-27 Yes 2025-01-27 bictegravir 203718 Biktarvy Gilead Sciences Canada, Inc.

N/A 2018-07-10 2024-07-10 Yes 2027-01-10 bilastine 184231 Blexten Aralez Pharmaceutials Canada Inc. N/A 2016-04-21 2022-04-21 Yes 2024-10-21 binimetinib 237410 Mektovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 blinatumomab 181723 can i take viagra every day Blincyto Amgen Canada Incorporated N/A 2015-12-22 2021-12-22 Yes 2024-06-22 bosutinib 152211 Bosulif Pfizer Canada Inc. N/A 2014-03-07 2020-03-07 N/A 2022-03-07 botulism antitoxin heptavalen C/ D/ F/ G - (equine) 190645 Bat Emergent BioSolutions Inc.

N/A 2016-12-08 2022-12-08 Yes 2025-06-08 brexpiprazole 192684 Rexulti Otsuka Pharmaceutical Co. Ltd. N/A 2017-02-16 2023-02-16 Yes 2025-08-16 brexucabtagene autoleucel 246355 Tecartus Gilead Sciences Canada, Inc.

N/A 2021-06-08 2027-06-08 N/A 2029-06-08 brigatinib 210369 Alunbrig Takeda Canada Incorporated N/A 2018-07-26 2024-07-26 N/A 2026-07-26 brivaracetam 183355 Brivlera UCB Canada Incorporated N/A 2016-03-09 2022-03-09 Yes 2024-09-09 brodalumab 195317 Siliq Bausch Health, Canada Inc. N/A 2018-03-06 2024-03-06 N/A 2026-03-06 brolucizumab 226224 Beovu Novartis Pharmaceuticals Canada Inc. N/A 2020-03-12 2026-03-12 N/A 2028-03-12 bromfenac sodium sesquihydrate 171657 Prolensa Bausch &.

Lomb Incorporated N/A 2015-03-26 2021-03-26 N/A 2023-03-26 burosumab 216239 Crysvita Kyowa Kirin Limited N/A 2018-12-05 2024-12-05 Yes 2027-06-05 cabotegravir sodium 227315 Vocabria ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabotegravir 227315 Cabenuva ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabozantinib (supplied as cabozantinib (S)-malate) 206230 Cabometyx Ipsen Biopharmaceuticals Canada Inc. N/A 2018-09-14 2024-09-14 N/A 2026-09-14 calcifediol 205392 Rayaldee Vifor Fresenius Medical Care Renal Pharma Ltd N/A 2018-07-10 2024-07-10 N/A 2026-07-10 canagliflozin 157505 Invokana Janssen Inc. InvokametInvokamet XR 2014-05-23 2020-05-23 N/A 2022-05-23 caplacizumab 230001 Cablivi Sanofi-Aventis Canada Inc.

N/A 2020-02-28 2026-02-28 N/A 2028-02-28 carfilzomib 184479 Kyprolis Amgen Canada Inc. N/A 2016-01-15 2022-01-15 N/A 2024-01-15 carglumic acid 171358 Carbaglu Recordati Rare Diseases N/A 2015-04-10 2021-04-10 Yes 2023-10-10 cedazuridine 234610 Inqovi Otsuka Pharmaceutical Co., Ltd. N/A 2020-07-07 2026-07-07 N/A 2028-07-07 ceftolozane 178006 Zerbaxa Merck Canada Inc.

N/A 2015-09-30 2021-09-30 N/A 2023-09-30 cemiplimab 218718 Libtayo Sanofi-Aventis Canada Inc. N/A 2019-04-10 2025-04-10 N/A 2027-04-10 cenegermin 218145 Oxervate Dompé farmaceutici S.p.A. N/A 2019-02-08 2025-02-08 N/A 2027-02-08 ceritinib 175702 Zykadia Novartis Pharmaceuticals Canada Inc.

N/A 2015-03-27 2021-03-27 N/A 2023-03-27 cerliponase alfa 216539 Brineura Biomarin International Limited N/A 2018-12-19 2024-12-19 Yes 2027-06-19 coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) 180793 Idelvion CSL Behring Canada Inc. N/A 2016-01-26 2022-01-26 Yes 2024-07-26 coagulation factor IX (recombinant), pegylated (nonacog beta pegol) 201114 Rebinyn Novo Nordisk Canada Inc. N/A 2017-11-29 2023-11-29 Yes 2026-05-29 coagulation factor IX, Fc fusion protein 163614 Alprolix Sanofi-Aventis Canada Inc.

N/A 2014-03-20 2020-03-20 Yes 2022-09-20 cobimetinib 182788 Cotellic Hoffmann-La Roche Limited N/A 2016-02-22 2022-02-22 N/A 2024-02-22 crisaborole 206906 Eucrisa Pfizer Canada Inc. N/A 2018-06-07 2024-06-07 Yes 2026-12-07 cysteamine bitartrate 191347 Procysbi Horizon Pharma Ireland Ltd. N/A 2017-06-13 2023-06-13 Yes 2025-12-13 daclatasvir 172616 Daklinza Bristol-Myers Squibb Canada N/A 2015-08-13 2021-08-13 N/A 2023-08-13 daclizumab beta 190458 Zinbryta Biogen Canada Inc.

N/A 2016-12-08 2022-12-08 N/A 2024-12-08 dacomitinib 214572 Vizimpro Pfizer Canada Inc. N/A 2019-02-26 2025-02-26 N/A 2027-02-26 dalbavancin (supplied as dalbavancin hydrochloride) 212390 Xydalba Cipher Pharmaceuticals Inc. N/A 2018-09-04 2024-09-04 N/A 2026-09-04 dapagliflozin propanediol 160877 Forxiga AstraZeneca Canada Inc.

XigduoQtern 2014-12-12 2020-12-12 N/A 2022-12-12 daratumumab 187648 Darzalex Janssen Inc. Darzalex SC 2016-06-29 2022-06-29 N/A 2024-06-29 darolutamide 226146 Nubeqa Bayer Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 deferiprone 162924 Ferriprox Chiesi Canada Corp.

N/A 2015-02-13 2021-02-13 Yes 2023-08-13 defibrotide sodium 200808 Defitelio Jazz Pharmaceuticals Ireland Limited N/A 2017-07-10 2023-07-10 Yes 2026-01-10 difluprednate 154517 Durezol Novartis Pharmaceuticals Canada Inc. N/A 2013-11-04 2019-11-04 Yes 2022-05-04 dinutuximab 212066 Unituxin United Therapeutics Corporation N/A 2018-11-28 2024-11-28 Yes 2027-05-28 dolutegravir sodium 161084 Tivicay ViiV Healthcare ULC TriumeqJulucaDovato 2013-10-31 2019-10-31 Yes 2022-05-01 doravirine 211293 Pifeo Merck Canada Inc. Delstrigo 2018-10-12 2024-10-12 N/A 2026-10-12 dulaglutide 168671 Trulicity Eli Lilly Canada Inc.

N/A 2015-11-10 2021-11-10 N/A 2023-11-10 dupilumab 201285 Dupixent Sanofi-Aventis Canada Inc. N/A 2017-11-30 2023-11-30 Yes 2026-05-30 durvalumab 202953 Imfinzi AstraZeneca Canada Inc. N/A 2017-11-03 2023-11-03 N/A 2025-11-03 edaravone 214391 Radicava Mitsubishi Tanabe Pharma Corporation N/A 2018-10-03 2024-10-03 N/A 2026-10-03 edoxaban 187363 Lixiana Servier Canada Inc.

N/A 2016-11-04 2022-11-04 N/A 2024-11-04 elagolix 209513 Orilissa AbbVie Corporation N/A 2018-10-05 2024-10-05 N/A 2026-10-05 elasomeran 252733 Spikevax ModernaTX, Inc. N/A 2021-09-16 2027-09-16 Yes 2030-03-16 elexacaftor 246955 Trikafta Vertex Pharmaceuticals (Canada) Incorporated N/A 2021-06-18 2027-06-18 Yes 2029-12-18 eliglustat tartrate 183050 Cerdelga Genzyme Canada, A division of Sanofi-aventis Canada Inc. N/A 2017-04-21 2023-04-21 N/A 2025-04-21 elosulfase alfa 170340 Vimizim Biomarin International Limited N/A 2014-07-02 2020-07-02 Yes 2023-01-02 elotuzumab 188144 Empliciti Bristol-Myers Squibb Canada N/A 2016-06-21 2022-06-21 N/A 2024-06-21 eluxadoline 190162 Viberzi Allergan inc.

N/A 2017-01-26 2023-01-26 N/A 2025-01-26 emicizumab 212635 Hemlibra Hoffmann-La Roche Limited N/A 2018-08-02 2024-08-02 Yes 2027-02-02 empagliflozin 162552 Jardiance Boehringer Ingelheim (Canada) Ltd. SynjardyGlyxambi 2015-07-23 2021-07-23 N/A 2023-07-23 enasidenib mesylate 217033 Idhifa Celgene Inc. N/A 2019-02-06 2025-02-06 N/A 2027-02-06 encorafenib 237413 Braftovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 enfortumab vedotin 251438 Padcev Seagen Inc.

N/A 2021-10-29 2027-10-29 N/A 2029-10-29 entrectinib 227517 Rozlytrek Hoffmann-La Roche Limited N/A 2020-02-10 2026-02-10 Yes 2028-08-10 eptinezumab 233288 Vyepti Lundbeck Canada Inc. N/A 2021-01-11 2027-01-11 N/A 2029-01-11 erdafitinib 224529 Balversa Janssen Inc. N/A 2019-10-25 2025-10-25 N/A 2027-10-25 erenumab 208607 Aimovig Novartis Pharmaceuticals Canada Inc.

N/A 2018-08-01 2024-08-01 N/A 2026-08-01 ertugliflozin 204724 Steglatro Merck Canada Inc. SteglujanSegluromet 2018-05-09 2024-05-09 N/A 2026-05-09 eslicarbazepine acetate 165665 Aptiom Sunovion Pharmaceuticals Canada Inc. N/A 2014-07-08 2020-07-08 Yes 2023-01-08 estetrol monohydrate 236197 Nextstellis Searchlight Pharma Inc.

N/A 2021-03-05 2027-03-05 N/A 2029-03-05 evolocumab 178234 Repatha Amgen Canada Inc. N/A 2015-09-10 2021-09-10 Yes 2024-03-10 fedratinib (supplied as fedratinib hydrochloride) 229866 Inrebic Celgene Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 ferric derisomaltose 193890 Monoferric Pharmacosmos A/S N/A 2018-06-22 2024-06-22 N/A 2026-06-22 ferric pyrophosphate citrate 239850 Triferic Avnu Rockwell Medical Inc.

N/A 2021-04-22 2027-04-22 Yes 2029-10-22 finafloxacin 172450 Xtoro MerLion Pharmaceuticals GmbH N/A 2016-03-11 2022-03-11 Yes 2024-09-11 flibanserin 189352 Addyi Searchlight Pharma Inc. N/A 2018-02-27 2024-02-27 N/A 2026-02-27 florbetaben (18F) 193105 Neuraceq Isologic Innovative Radiopharmaceuticals Ltd. N/A 2017-02-22 2023-02-22 N/A 2025-02-22 follitropin delta 188743 Rekovelle Ferring Inc.

N/A 2018-03-22 2024-03-22 N/A 2026-03-22 fostamatinib (supplied as fostamatinib disodium) 232078 Tavalisse Medison Pharma Canada Inc. N/A 2020-11-19 2026-11-19 N/A 2028-11-19 fostemsavir (supplied as fostemsavir tromethamine) 250213 Rukobia Viiv Healthcare ULC N/A 2021-10-01 2027-10-01 N/A 2029-10-01 fremanezumab 226828 Ajovy Teva Canada Limited N/A 2020-04-09 2026-04-09 N/A 2028-04-09 gadoterate meglumine 186333 Dotarem Guerbet N/A 2016-11-26 2022-11-26 Yes 2025-05-26 galcanezumab 219521 Emgality Eli Lilly Canada Inc. N/A 2019-07-30 2025-07-30 N/A 2027-07-30 galsulfase 159020 Naglazyme BioMarin Pharmaceutical Inc.

N/A 2013-09-16 2019-09-16 Yes 2022-03-16 gemtuzumab ozogamicin 223091 Mylotarg Pfizer Canada ULC N/A 2019-11-28 2025-11-28 Yes 2028-05-28 gilteritinib fumarate 227918 Xospata Astellas Pharma Canada Inc. N/A 2019-12-23 2025-12-23 N/A 2027-12-23 givosiran (supplied as givosiran sodium) 237194 Givlaari Alnylam Netherlands B.V.. N/A 2020-10-09 2026-10-09 N/A 2028-10-09 glasdegib 225793 Daurismo Pfizer Canada ULC N/A 2020-04-28 2026-04-28 N/A 2028-04-28 glecaprevir, pibrentasvir 202233 Maviret AbbVie Corporation N/A 2017-08-16 2023-08-16 Yes 2026-02-16 glycerol phenylbutyrate 174219 Ravicti Horizon Pharma Ireland Ltd.

N/A 2016-03-18 2022-03-18 Yes 2024-09-18 grazoprevir, elbasvir 185866 Zepatier Merck Canada Inc. N/A 2016-01-19 2022-01-19 N/A 2024-01-19 guanfacine hydrochloride 150741 Intuniv XR Takeda Canada Inc. N/A 2013-07-05 2019-07-05 Yes 2022-01-05 guselkumab 200590 Tremfya Janssen Inc.

N/A 2017-11-10 2023-11-10 N/A 2025-11-10 hemin 212276 Panhematin Recordati Rare Diseases Canada Inc. N/A 2018-07-13 2024-07-13 N/A 2026-07-13 ibrutinib 174029 Imbruvica Janssen Inc. N/A 2014-11-17 2020-11-17 Yes 2023-05-17 icatibant acetate 162918 Firazyr Takeda Canada Inc.

N/A 2014-06-04 2020-06-04 Yes 2022-12-04 icosapent ethyl 227235 Vascepa HLS Therapeutics Inc. N/A 2019-12-30 2025-12-30 N/A 2027-12-30 idarucizumab 182503 Praxbind Boehringer Ingelheim (Canada) Ltd N/A 2016-04-29 2022-04-29 N/A 2024-04-29 idecabtagene vicleucel 244266 Abecma Celgene Inc. N/A 2021-05-26 2027-05-26 N/A 2029-05-26 idelalisib 172652 Zydelig Gilead Sciences Canada Inc.

N/A 2015-03-27 2021-03-27 N/A 2023-03-27 inclisiran sodium 243470 Leqvio Novartis Pharmaceuticals Canada Inc. N/A 2021-07-26 2027-07-26 N/A 2029-07-26 infigratinib (supplied as infigratinib phosphate) 246904 Truseltiq QED Therapeutics, Inc. N/A 2021-09-27 2027-09-27 N/A 2029-09-27 inotersen sodium 214274 Tegsedi Akcea Therapeutics Inc.

N/A 2018-10-03 2024-10-03 N/A 2026-10-03 inotuzumab ozogamicin 204077 Besponsa Pfizer Canada Inc. N/A 2018-03-15 2024-03-15 N/A 2026-03-15 insulin degludec 198124 Tresiba Novo Nordisk Canada Inc. Xultophy 2017-08-25 2023-08-25 Yes 2026-02-25 ioflupane (123I) 201481 Datscan GE Healthcare Canada Inc.

N/A 2017-12-07 2023-12-07 N/A 2025-12-07 isatuximab 229245 Sarclisa Sanofi-Aventis Canada Inc. N/A 2020-04-29 2026-04-29 N/A 2028-04-29 isavuconazole (supplied as isavuconazonium sulfate) 208919 Cresemba Avir Pharma Inc. N/A 2018-12-19 2024-12-19 N/A 2026-12-19 ivabradine hydrochloride 166949 Lancora Servier Canada Inc.

N/A 2016-12-23 2022-12-23 Yes 2025-06-23 ivermectin 172733 Rosiver Galderma Canada Inc. N/A 2015-04-22 2021-04-22 N/A 2023-04-22 ixazomib (supplied as ixazomib citrate) 190498 Ninlaro Takeda Canada Inc. N/A 2016-08-04 2022-08-04 N/A 2024-08-04 ixekizumab 184993 Taltz Eli Lilly Canada Inc.

N/A 2016-05-25 2022-05-25 Yes 2024-11-25 lanadelumab 213920 Takhzyro Takeda Canada Inc. N/A 2018-09-19 2024-09-19 Yes 2027-03-19 larotrectinib (supplied as larotrectinib sulfate) 219998 Vitrakvi Bayer Inc. N/A 2019-07-10 2025-07-10 Yes 2028-01-10 latanoprostene bunod 211732 Vyzulta Bausch &.

Lomb Incorporated N/A 2018-12-27 2024-12-27 N/A 2026-12-27 ledipasvir 173180 Harvoni Gilead Sciences Canada Inc. N/A 2014-10-15 2020-10-15 Yes 2023-04-15 lefamulin acetate 233292 Xenleta Sunovion Pharmaceuticals Canada Inc. N/A 2020-07-10 2026-07-10 N/A 2028-07-10 lemborexant 231286 Dayvigo Eisai Limited N/A 2020-11-04 2026-11-04 N/A 2028-11-04 lenvatinib mesylate 180877 Lenvima Eisai Limited N/A 2015-12-22 2021-12-22 Yes 2024-06-22 letermovir 204165 Prevymis Merck Canada Inc.

N/A 2017-11-01 2023-11-01 N/A 2025-11-01 levomilnacipran hydrochloride 167319 Fetzima Allergan Inc. N/A 2015-05-08 2021-05-08 N/A 2023-05-08 lifitegrast 199810 Xiidra Novartis Pharmaceuticals Canada Inc. N/A 2017-12-22 2023-12-22 N/A 2025-12-22 linaclotide 161056 Constella Forest Laboratories Canada Inc.

N/A 2013-12-02 2019-12-02 N/A 2021-12-02 lixisenatide 193862 Adlyxine Sanofi-aventis Canada Inc. Soliqua 2017-05-25 2023-05-25 N/A 2025-05-25 lomitapide mesylate 160385 Juxtapid Aegerion Pharmaceuticals Canada Ltd. N/A 2014-02-04 2020-02-04 N/A 2022-02-04 lorlatinib 215733 Lorbrena Pfizer Canada ULC N/A 2019-02-22 2025-02-22 N/A 2027-02-22 lubiprostone 179333 Amitiza Sucampo Pharma Americas LLC N/A 2015-10-14 2021-10-14 N/A 2023-10-14 lumacaftor 181715 Orkambi Vertex Pharmaceuticals (Canada) Incorporated N/A 2016-01-26 2022-01-26 Yes 2024-07-26 lurbinectedin 247485 Zepzelca Jazz Pharmaceuticals Ireland Limited N/A 2021-09-29 2027-09-29 N/A 2029-09-29 luspatercept 236441 Reblozyl Celgene Inc.

N/A 2020-09-25 2026-09-25 N/A 2028-09-25 lutetium177 Lu oxodotreotide 217184 Lutathera Advanced Accelerator Applications USA, Inc. N/A 2019-01-09 2025-01-09 N/A 2027-01-09 macitentan 161372 Opsumit Janssen Inc. Opsynvi 2013-11-06 2019-11-06 Yes 2022-05-06 mecasermin 235023 Increlex Ipsen Biopharmaceuticals Canada Inc.

N/A 2020-12-17 2026-12-17 Yes 2029-06-17 mepolizumab 179850 Nucala GlaxoSmithKline Inc. N/A 2015-12-03 2021-12-03 Yes 2024-06-03 midostaurin 201101 Rydapt Novartis Pharmaceuticals Canada Inc. N/A 2017-07-21 2023-07-21 Yes 2026-01-21 mifepristone 160063 Mifegymiso Linepharma International Limited N/A 2015-07-29 2021-07-29 Yes 2024-01-29 migalastat hydrochloride 196956 Galafold Amicus Therapeutics UK LTD N/A 2017-09-05 2023-09-05 N/A 2025-09-05 modified vaccinia viagra (ankara-bavarian nordic) 144762 Imvamune Bavarian Nordic A/S N/A 2013-11-21 2019-11-21 N/A 2021-11-21 naloxegol oxalate 167790 Movantik Knight Therapeutics Inc.

N/A 2015-06-02 2021-06-02 N/A 2023-06-02 necitumumab 193689 Portrazza Eli Lilly Canada Inc. N/A 2017-03-16 2023-03-16 N/A 2025-03-16 neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily A and Neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily B 195550 Trumenba Pfizer Canada Inc. N/A 2017-10-05 2023-10-05 Yes 2026-04-05 neratinib maleate 218224 Nerlynx Knight Therapeutics Inc.

N/A 2019-07-16 2025-07-16 N/A 2027-07-16 netupitant 196495 Akynzeo Elvium Life Sciences N/A 2017-09-28 2023-09-28 N/A 2025-09-28 nintedanib (supplied as nintedanib esilate) 176043 Ofev Boehringer Ingelheim (Canada) Ltd N/A 2015-06-25 2021-06-25 N/A 2023-06-25 niraparib 216792 Zejula GlaxoSmithKline Inc. N/A 2019-06-27 2025-06-27 N/A 2027-06-27 nivolumab 180828 Opdivo Bristol-Myers-Squibb Canada N/A 2015-09-25 2021-09-25 Yes 2024-03-25 nusinersen 200070 Spinraza Biogen Canada Inc. N/A 2017-06-29 2023-06-29 Yes 2025-12-29 obeticholic acid 198418 Ocaliva Intercept Pharmaceuticals Inc.

N/A 2017-05-24 2023-05-24 N/A 2025-05-24 obiltoxaximab 230825 Anthim Elusys Therapeutics, Inc. N/A 2020-07-30 2026-07-30 N/A 2028-07-30 obinutuzumab 168227 Gazyva Hoffmann-La Roche Limited N/A 2014-11-25 2020-11-25 N/A 2022-11-25 ocrelizumab 198094 Ocrevus Hoffmann-La Roche Limited N/A 2017-08-14 2023-08-14 N/A 2025-08-14 olaparib 182823 Lynparza AstraZeneca Canada Inc. N/A 2016-04-29 2022-04-29 N/A 2024-04-29 olaratumab 203478 Lartruvo Eli Lilly Canada Inc.

N/A 2017-11-23 2023-11-23 N/A 2025-11-23 ombitasvir, paritaprevir, dasabuvir sodium 174739 Holkira Pak Abbvie Corporation Technivie 2014-12-22 2020-12-22 N/A 2022-12-22 onasemnogene abeparvovec 239719 Zolgensma Novartis Pharmaceuticals Canada Inc. N/A 2020-12-15 2026-12-15 Yes 2029-06-15 osimertinib mesylate 188171 Tagrisso AstraZeneca Canada Inc. N/A 2016-07-05 2022-07-05 N/A 2024-07-05 ospemifene 222001 Osphena Duchesnay Inc.

N/A 2021-07-16 2027-07-16 N/A 2029-07-16 ozanimod (supplied as ozanimod hydrochloride) 232761 Zeposia Celgene Inc. N/A 2020-10-02 2026-10-02 N/A 2028-10-02 ozenoxacin 192925 Ozanex Ferrer Internacional, S.A. N/A 2017-05-01 2023-05-01 Yes 2025-11-01 palbociclib 182048 Ibrance Pfizer Canada Inc.

N/A 2016-03-16 2022-03-16 Yes 2024-09-16 patiromer sorbitex calcium 210368 Veltassa Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 patisiran (as patisiran sodium) 221896 Onpattro Alnylam Netherlands B.V. N/A 2019-06-07 2025-06-07 N/A 2027-06-07 peginterferon beta-1a 166974 Plegridy Biogen Idec Canada Inc.

N/A 2015-08-10 2021-08-10 N/A 2023-08-10 pembrolizumab 175884 Keytruda Merck Canada Inc. N/A 2015-05-19 2021-05-19 Yes 2023-11-19 pemigatinib 242569 Pemazyre Incyte Corporation N/A 2021-09-17 2027-09-17 N/A 2029-09-17 peramivir 191280 Rapivab BioCryst Pharmaceuticals Inc. N/A 2017-01-05 2023-01-05 N/A 2025-01-05 pitolisant hydrochloride 238175 Wakik Endo Ventures Ltd.

N/A 2021-05-25 2027-05-25 N/A 2029-05-25 plecanatide 215288 Trulance Bausch Health, Canada Inc. N/A 2019-10-10 2025-10-10 N/A 2027-10-10 polatuzumab vedotin 232303 Polivy Hoffmann-La Roche Limited N/A 2020-07-09 2026-07-09 N/A 2028-07-09 polidocanol 177359 Varithena Provensis Ltd. N/A 2015-08-04 2021-08-04 N/A 2023-08-04 pomalidomide 165891 Pomalyst Celgene Inc.

N/A 2014-01-20 2020-01-20 Yes 2022-07-20 pralatrexate 207545 Folotyn Servier Canada Inc. N/A 2018-10-26 2024-10-26 N/A 2026-10-26 pralsetinib 243731 Gavreto Hoffmann-La Roche Limited N/A 2021-06-30 2027-06-30 N/A 2029-06-30 prasterone 198822 Intrarosa Endoceutics Inc. N/A 2019-11-01 2025-11-01 N/A 2027-11-01 ponatinib hydrochloride 165121 Iclusig Ariad Pharmaceuticals Inc.

N/A 2015-04-02 2021-04-02 N/A 2023-04-02 ponesimod 239537 Ponvory Janssen Inc. N/A 2021-04-28 2027-04-28 N/A 2029-04-28 propiverine hydrochloride 188323 Mictoryl / Mictoryl Pediatric Duchesnay Inc. N/A 2017-01-05 2023-01-05 Yes 2025-07-05 radium - 223 dichloride 161312 Xofigo Bayer Inc.

N/A 2013-12-12 2019-12-12 N/A 2021-12-12 ramucirumab 176810 Cyramza Eli Lilly Canada Inc. N/A 2015-07-16 2021-07-16 N/A 2023-07-16 ravulizumab 217955 Ultomiris Alexion Pharma GmbH N/A 2019-08-28 2025-08-28 N/A 2027-08-28 recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) 235672 Supemtek Sanofi Pasteur Limited N/A 2021-01-14 2027-01-14 N/A 2029-01-14 recombinant human papillomaviagra types 31, 33, 45, 52 and 58 170006 Gardasil 9 Merck Canada Inc. N/A 2015-02-05 2021-02-05 Yes 2023-08-05 recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) 147275 Bexsero GlaxoSmithKline Inc.

N/A 2013-12-06 2019-12-06 Yes 2022-06-06 recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) 177290 Obizur Takeda Canada Inc. N/A 2015-10-14 2021-10-14 N/A 2023-10-14 remdesivir 240551 Veklury Gilead Sciences Canada, Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 reslizumab 185873 Cinqair Teva Canada Limited N/A 2016-07-20 2022-07-20 Yes 2025-01-20 ribociclib (supplied as ribociclib succinate) 203884 Kisqali Novartis Pharmaceuticals Canada Inc.

N/A 2018-03-02 2024-03-02 N/A 2026-03-02 ripretinib 234688 Qinlock Deciphera Pharmaceuticals, LLC N/A 2020-06-19 2026-06-19 N/A 2028-06-19 risankizumab 215753 Skyrizi AbbVie Corporation N/A 2019-04-17 2025-04-17 N/A 2027-04-17 risdiplam 242373 Evrysdi Hoffman-La Roche Limited N/A 2021-04-14 2027-04-14 Yes 2029-10-14 romosozumab 197713 Evenity Amgen Canada Inc. N/A 2019-06-17 2025-06-17 N/A 2027-06-17 rupatadine (supplied as rupatadine fumarate) 186488 Rupall Medexus Pharmaceuticals Inc. N/A 2016-07-20 2022-07-20 Yes 2025-01-20 sacituzumab govitecan 248753 Trodelvy Gilead Sciences Canada, Inc.

N/A 2021-09-24 2027-09-24 N/A 2029-09-24 sacubitril 182734 Entresto Novartis Pharmaceuticals Canada Inc. N/A 2015-10-02 2021-10-02 Yes 2024-04-02 safinamide (as safinamide mesylate) 207115 Onstryv Valeo Pharma Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 sarilumab 191745 Kevzara Sanofi-aventis Canada Inc.

N/A 2017-01-12 2023-01-12 N/A 2025-01-12 satralizumab 233642 Enspryng Hoffmann-La Roche Limited N/A 2020-06-01 2026-06-01 Yes 2028-12-01 sebelipase alfa 204085 Kanuma Alexion Pharma GmbH N/A 2017-12-15 2023-12-15 Yes 2026-06-15 secukinumab 170732 Cosentyx Novartis Pharmaceuticals Canada Inc. N/A 2015-02-27 2021-02-27 Yes 2023-08-27 selexipag 182114 Uptravi Janssen Inc. N/A 2016-01-20 2022-01-20 Yes 2024-07-20 selpercatinib 243748 Retevmo Loxo Oncology Inc.

N/A 2021-06-15 2027-06-15 Yes 2029-12-15 semaglutide 202059 Ozempic Novo Nordisk Canada Inc. Rybelsus 2018-01-04 2024-01-04 N/A 2026-01-04 siltuximab 174291 Sylvant EUSA Pharma (UK) Limited N/A 2014-12-03 2020-12-03 N/A 2022-12-03 siponimod 223225 Mayzent Novartis Pharmaceuticals Canada Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 sodium zirconium cyclosilicate 218799 Lokelma AstraZeneca Canada Inc.

N/A 2019-07-25 2025-07-25 N/A 2027-07-25 sofosbuvir 165043 Sovaldi Gilead Sciences Canada Inc. HarvoniEpclusaVosevi 2013-12-13 2019-12-13 N/A 2021-12-13 solriamfetol hydrochloride 237511 Sunosi Jazz Pharmaceuticals Ireland Ltd. N/A 2021-05-13 2027-05-13 N/A 2029-11-13 somatrogon 246729 Ngenla Pfizer Canada ULC N/A 2021-10-26 2027-10-26 Yes 2030-04-26 sonidegib phosphate 229407 Odomzo Sun Pharma Global FZE N/A 2020-06-12 2026-06-12 N/A 2028-06-12 sotorasib 248435 Lumakras Amgen Canada Inc.

N/A 2021-09-10 2027-09-10 N/A 2029-09-10 sucroferric oxyhydroxide 201492 Velphoro Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-01-05 2024-01-05 N/A 2026-01-05 sugammadex sodium 180385 Bridion Merck Canada Inc. N/A 2016-02-05 2022-02-05 Yes 2024-08-05 suvorexant 196367 Belsomra Merck Canada Inc.

N/A 2018-11-29 2024-11-29 N/A 2026-11-29 tafamidis meglumine 228368 Vyndaqel Pfizer Canada ULC Vyndamax 2020-01-20 2026-01-20 N/A 2028-01-20 tafasitamab 247025 Minjuvi Incyte Corporation N/A 2021-08-19 2027-08-19 N/A 2029-08-19 tafluprost 165596 Saflutan Purdue Pharma N/A 2014-05-26 2020-05-26 N/A 2022-05-26 talazoparib (supplied as talazoparib tosylate) 220584 Talzenna Pfizer Canada ULC N/A 2019-09-06 2025-09-06 N/A 2027-09-06 taliglucerase alfa 140854 Elelyso Pfizer Canada Inc. N/A 2014-05-29 2020-05-29 Yes 2022-11-29 tedizolid phosphate 173603 Sivextro Merck Canada Inc. N/A 2015-03-17 2021-03-17 N/A 2023-03-17 teduglutide 180223 Revestive Takeda Canada Inc.

N/A 2015-09-04 2021-09-04 Yes 2024-03-04 telotristat ethyl (as telotristat etiprate) 208730 Xermelo Ipsen Biopharmaceuticals Canada Inc. N/A 2018-10-10 2024-10-10 N/A 2026-10-10 tenapanor hydrochloride 224850 Ibsrela Knight Therapeutics Inc. N/A 2020-04-15 2026-04-15 N/A 2028-04-15 tenofovir alafenamide hemifumarate 181399 Genvoya Gilead Sciences Canada Inc.

DescovyOdefseyVemlidySymtuzaBiktarvy 2015-11-27 2021-11-27 Yes 2024-05-27 tepotinib (supplied as tepotinib hydrochloride) 242300 Tepmetko EMD Serono, a Division of EMD Inc., Canada N/A 2021-05-27 2027-05-27 N/A 2029-05-27 teriflunomide 160646 Aubagio Genzyme Canada a division of Sanofi-aventis Canada Inc. N/A 2013-11-14 2019-11-14 Yes 2022-05-14 tesamorelin 131836 Egrifta Theratechnologies Inc. N/A 2014-04-29 2020-04-29 N/A 2022-04-29 tezacaftor 211292 Symdeko Vertex Pharmaceuticals (Canada) Incorporated N/A 2018-06-27 2024-06-27 Yes 2026-12-27 tildrakizumab 224036 Ilumya Sun Pharma Global FZE N/A 2021-05-19 2027-05-19 N/A 2029-05-19 tisagenlecleucel 213547 / 213698 Kymriah Novartis Pharmaceuticals Canada Inc.

N/A 2018-09-05 2024-09-05 Yes 2027-03-05 tofacitinib 154642 Xeljanz Pfizer Canada Inc. N/A 2014-04-17 2020-04-17 Yes 2022-10-17 tozinameran 252736 Comirnaty BioNTech Manufacturing GmbH N/A 2021-09-16 2027-09-16 Yes 2030-03-16 tralokinumab 245877 Adtralza LEO Pharma Inc. N/A 2021-10-13 2027-10-13 N/A 2029-10-13 trastuzumab deruxtecan 242104 Enhertu AstraZeneca Canada Inc.

N/A 2021-04-15 2027-04-15 N/A 2029-04-15 trifarotene 221945 Aklief Galderma Canada Inc. N/A 2019-11-25 2025-11-25 Yes 2028-05-25 tipiracil hydrochloride 205852 Lonsurf Taiho Pharma Canada Inc. N/A 2018-01-25 2024-01-25 N/A 2026-01-25 triheptanoin 242196 Dojolvi Uagenyx Pharmaceutical Inc.

N/A 2021-02-15 2027-02-15 Yes 2029-08-15 tucatinib 235295 Tukysa Seagen Inc. N/A 2020-06-05 2026-06-05 N/A 2028-06-05 turoctocog alfa 170796 Zonovate Novo Nordisk Canada Inc. N/A 2014-12-08 2020-12-08 Yes 2023-06-08 umeclidinium bromide 161585 Anoro Ellipta GlaxoSmithKline Inc.

Incruse Ellipta 2013-12-23 2019-12-23 N/A 2021-12-23 upadacitinib 223734 Rinvoq AbbVie Corporation N/A 2019-12-23 2025-12-23 Yes 2028-06-23 varicella-zoster viagra glycoprotein E (gE) 200244 Shingrix GlaxoSmithKline Inc. N/A 2017-10-13 2023-10-13 N/A 2025-10-13 vedolizumab 169414 Entyvio Takeda Canada Inc. N/A 2015-01-29 2021-01-29 Yes 2023-07-29 velpatasvir 190521 Epclusa Gilead Sciences Canada Inc.

Vosevi 2016-07-11 2022-07-11 Yes 2025-01-11 venetoclax 190761 Venclexta AbbVie Corporation N/A 2016-09-30 2022-09-30 N/A 2024-09-30 vernakalant hydrochloride 190817 Brinavess Cipher Pharmaceuticals Inc. N/A 2017-03-13 2023-03-13 N/A 2025-03-13 vilanterol trifenatate 157301 Breo Ellipta GlaxoSmithKline Inc. Anoro ElliptaTrelegy Ellipta 2013-07-03 2019-07-03 Yes 2022-01-03 vilazodone hydrochloride 176820 Viibryd Allergan Inc.

N/A 2015-07-16 2021-07-16 Yes 2024-01-16 von willebrand factor (recombinant) (vonicog alfa) 213188 Vonvendi Takeda Canada Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 vorapaxar sulfate 179320 Zontivity Toprol Acquisition LLC N/A 2016-05-13 2022-05-13 N/A 2024-05-13 voretigene neparvovec 233097 Luxturna Novartis Pharmaceuticals Canada Inc. N/A 2020-10-13 2026-10-13 Yes 2029-04-13 vortioxetine hydrobromide 159019 Trintellix Lundbeck Canada Inc.

N/A 2014-10-22 2020-10-22 Yes 2023-04-22 voxilaprevir 202324 Vosevi Gilead Sciences Canada Inc. N/A 2017-08-16 2023-08-16 N/A 2025-08-16 zanubrutinib 242748 Brukinsa BeiGene Switzerland GmbH N/A 2021-03-01 2027-03-01 N/A 2029-03-01.

Abemaciclib 215268 viagra cost Verzenio Eli Lilly Canada Inc. N/A 2019-04-08 2025-04-08 N/A 2027-04-08 acalabrutinib 214504 Calquence AstraZeneca Canada Inc. N/A 2019-08-23 2025-08-23 N/A 2027-08-23 viagra cost albiglutide 165145 Eperzan GlaxoSmithKline Inc.

N/A 2015-07-15 2021-07-15 N/A 2023-07-15 alectinib hydrochloride 189442 Alecensaro Hoffmann-La Roche Limited N/A 2016-09-29 2022-09-29 N/A 2024-09-29 alirocumab 183116 Praluent Sanofi-aventis Canada Inc. N/A 2016-04-11 2022-04-11 N/A 2024-04-11 alogliptin benzoate 158335 Nesina Takeda Canada Inc. KazanoOseni 2013-11-27 2019-11-27 N/A 2021-11-27 alpelisib viagra cost 226941 Piqray Novartis Pharmaceuticals Canada Inc.

N/A 2020-03-11 2026-03-11 N/A 2028-03-11 amifampridine (supplied as amifampridine phosphate) 232685 Firdapse Kye Pharmaceuticals Inc. N/A 2020-07-31 2026-07-31 N/A 2028-07-31 anthrax immune globulin (human) 200446 Anthrasil Emergent BioSolutions Canada Inc. N/A 2017-11-06 2023-11-06 Yes 2026-05-06 antihemophilic factor viagra cost (recombinant BDD), Fc fusion protein 163447 Eloctate Sanofi-Aventis Canada Inc.

N/A 2014-08-22 2020-08-22 Yes 2023-02-22 antihemophilic factor (recombinant), pegylated 189709 Adynovate Takeda Canada Inc. N/A 2016-11-17 2022-11-17 Yes 2025-05-17 antihemophilic factor (recombinant, B-domain deleted, pegylated) (also known as damoctocog alfa pegol) 210935 Jivi Bayer Inc. N/A 2018-10-18 2024-10-18 Yes 2027-04-18 antihemophilic factor (recombinant, B-domain deleted) (also known as simoctocog alfa) viagra cost 169551 Nuwiq Octapharma Pharmazeutika Produktionsges.m.b.H N/A 2014-10-23 2020-10-23 Yes 2023-04-23 antihemophilic factor VIII (recombinant), singlechain (also known as lonoctocog alfa) 190891 Afstyla CSL Behring Canada Inc.

N/A 2016-12-12 2022-12-12 Yes 2025-06-12 anthrax antigen fiate 212387 Biothrax Emergent Biodefense Operations Lansing LLC N/A 2018-12-13 2024-12-13 N/A 2026-12-13 antihemophilic factor VIII (recombinant, B-domain truncated), PEGylated (turoctocog alfa pegol) 218531 Esperoct Novo Nordisk Canada Inc. N/A 2019-07-04 2025-07-04 Yes 2028-01-04 apalutamide 211942 Erleada Janssen Inc. N/A 2018-07-03 2024-07-03 N/A 2026-07-03 apremilast viagra cost 169862 Otezla Amgen Canada Inc.

N/A 2014-11-12 2020-11-12 N/A 2022-11-12 asfotase alfa 179340 Strensiq Alexion Pharma International Sàrl N/A 2015-08-14 2021-08-14 Yes 2024-02-14 asunaprevir 172617 Sunvepra Bristol-Myers Squibb Canada N/A 2016-03-09 2022-03-09 N/A 2024-03-09 atezolizumab 196843 Tecentriq Hoffmann-La Roche Limited N/A 2017-04-12 2023-04-12 Yes 2025-10-12 avalglucosidase alfa 245680 Nexviazyme Sanofi-Aventis Canada Inc. N/A 2021-11-12 2027-11-12 Yes 2030-05-12 avelumab 204052 Bavencio EMD Serono, a Division of EMD Inc., Canada N/A 2017-12-18 2023-12-18 N/A 2025-12-18 axicabtagene ciloleucel 218389 Yescarta Gilead Sciences Canada Inc N/A 2019-02-13 2025-02-13 N/A 2027-02-13 azelastine hydrochloride 169604 Dymista Meda Pharmaceuticals Ltd. N/A 2014-10-23 2020-10-23 Yes 2023-04-23 viagra cost baloxavir marboxil 227361 Xofluza Hoffmann-La Roche Limited N/A 2020-02-19 2026-02-19 Yes 2028-08-19 baricitinib 193687 Olumiant Eli Lilly Canada Inc.

N/A 2018-08-17 2024-08-17 N/A 2026-08-17 bazedoxifene acetate 160681 Duavive Pfizer Canada Inc. N/A 2014-10-23 2020-10-23 N/A 2022-10-23 benralizumab 204008 Fasenra AstraZeneca Canada Inc. N/A 2018-02-22 2024-02-22 Yes 2026-08-22 bepotastine besilate 179294 Bepreve Bausch and Lomb Incorporated N/A 2016-07-27 viagra cost 2022-07-27 Yes 2025-01-27 bictegravir 203718 Biktarvy Gilead Sciences Canada, Inc.

N/A 2018-07-10 2024-07-10 Yes 2027-01-10 bilastine 184231 Blexten Aralez Pharmaceutials Canada Inc. N/A 2016-04-21 viagra cost 2022-04-21 Yes 2024-10-21 binimetinib 237410 Mektovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 blinatumomab 181723 Blincyto Amgen Canada Incorporated N/A 2015-12-22 2021-12-22 Yes 2024-06-22 bosutinib 152211 Bosulif Pfizer Canada Inc. N/A 2014-03-07 2020-03-07 N/A 2022-03-07 botulism antitoxin heptavalen C/ D/ F/ G - (equine) 190645 Bat Emergent BioSolutions Inc.

N/A 2016-12-08 2022-12-08 Yes 2025-06-08 brexpiprazole 192684 Rexulti Otsuka Pharmaceutical Co. Ltd. N/A 2017-02-16 2023-02-16 Yes 2025-08-16 brexucabtagene autoleucel 246355 Tecartus Gilead Sciences Canada, Inc.

N/A 2021-06-08 2027-06-08 N/A 2029-06-08 brigatinib 210369 Alunbrig Takeda Canada Incorporated N/A 2018-07-26 2024-07-26 N/A 2026-07-26 brivaracetam 183355 Brivlera UCB Canada Incorporated N/A 2016-03-09 2022-03-09 Yes 2024-09-09 brodalumab 195317 Siliq Bausch Health, Canada Inc. N/A 2018-03-06 2024-03-06 N/A 2026-03-06 brolucizumab 226224 Beovu Novartis Pharmaceuticals Canada Inc. N/A 2020-03-12 2026-03-12 N/A 2028-03-12 bromfenac sodium sesquihydrate 171657 Prolensa Bausch &.

Lomb Incorporated N/A 2015-03-26 2021-03-26 N/A 2023-03-26 burosumab 216239 Crysvita Kyowa Kirin Limited N/A 2018-12-05 2024-12-05 Yes 2027-06-05 cabotegravir sodium 227315 Vocabria ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabotegravir 227315 Cabenuva ViiV Healthcare ULC N/A 2020-03-18 2026-03-18 N/A 2028-03-18 cabozantinib (supplied as cabozantinib (S)-malate) 206230 Cabometyx Ipsen Biopharmaceuticals Canada Inc. N/A 2018-09-14 2024-09-14 N/A 2026-09-14 calcifediol 205392 Rayaldee Vifor Fresenius Medical Care Renal Pharma Ltd N/A 2018-07-10 2024-07-10 N/A 2026-07-10 canagliflozin 157505 Invokana Janssen Inc. InvokametInvokamet XR 2014-05-23 2020-05-23 N/A 2022-05-23 caplacizumab 230001 Cablivi Sanofi-Aventis Canada Inc.

N/A 2020-02-28 2026-02-28 N/A 2028-02-28 carfilzomib 184479 Kyprolis Amgen Canada Inc. N/A 2016-01-15 2022-01-15 N/A 2024-01-15 carglumic acid 171358 Carbaglu Recordati Rare Diseases N/A 2015-04-10 2021-04-10 Yes 2023-10-10 cedazuridine 234610 Inqovi Otsuka Pharmaceutical Co., Ltd. N/A 2020-07-07 2026-07-07 N/A 2028-07-07 ceftolozane 178006 Zerbaxa Merck Canada Inc.

N/A 2015-09-30 2021-09-30 N/A 2023-09-30 cemiplimab 218718 Libtayo Sanofi-Aventis Canada Inc. N/A 2019-04-10 2025-04-10 N/A 2027-04-10 cenegermin 218145 Oxervate Dompé farmaceutici S.p.A. N/A 2019-02-08 2025-02-08 N/A 2027-02-08 ceritinib 175702 Zykadia Novartis Pharmaceuticals Canada Inc.

N/A 2015-03-27 2021-03-27 N/A 2023-03-27 cerliponase alfa 216539 Brineura Biomarin International Limited N/A 2018-12-19 2024-12-19 Yes 2027-06-19 coagulation factor IX (recombinant), albumin fusion protein (rIX-FP) 180793 Idelvion CSL Behring Canada Inc. N/A 2016-01-26 2022-01-26 Yes 2024-07-26 coagulation factor IX (recombinant), pegylated (nonacog beta pegol) 201114 Rebinyn Novo Nordisk Canada Inc. N/A 2017-11-29 2023-11-29 Yes 2026-05-29 coagulation factor IX, Fc fusion protein 163614 Alprolix Sanofi-Aventis Canada Inc.

N/A 2014-03-20 2020-03-20 Yes 2022-09-20 cobimetinib 182788 Cotellic Hoffmann-La Roche Limited N/A 2016-02-22 2022-02-22 N/A 2024-02-22 crisaborole 206906 Eucrisa Pfizer Canada Inc. N/A 2018-06-07 2024-06-07 Yes 2026-12-07 cysteamine bitartrate 191347 Procysbi Horizon Pharma Ireland Ltd. N/A 2017-06-13 2023-06-13 Yes 2025-12-13 daclatasvir 172616 Daklinza Bristol-Myers Squibb Canada N/A 2015-08-13 2021-08-13 N/A 2023-08-13 daclizumab beta 190458 Zinbryta Biogen Canada Inc.

N/A 2016-12-08 2022-12-08 N/A 2024-12-08 dacomitinib 214572 Vizimpro Pfizer Canada Inc. N/A 2019-02-26 2025-02-26 N/A 2027-02-26 dalbavancin (supplied as dalbavancin hydrochloride) 212390 Xydalba Cipher Pharmaceuticals Inc. N/A 2018-09-04 2024-09-04 N/A 2026-09-04 dapagliflozin propanediol 160877 Forxiga AstraZeneca Canada Inc.

XigduoQtern 2014-12-12 2020-12-12 N/A 2022-12-12 daratumumab 187648 Darzalex Janssen Inc. Darzalex SC 2016-06-29 2022-06-29 N/A 2024-06-29 darolutamide 226146 Nubeqa Bayer Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 deferiprone 162924 Ferriprox Chiesi Canada Corp.

N/A 2015-02-13 2021-02-13 Yes 2023-08-13 defibrotide sodium 200808 Defitelio Jazz Pharmaceuticals Ireland Limited N/A 2017-07-10 2023-07-10 Yes 2026-01-10 difluprednate 154517 Durezol Novartis Pharmaceuticals Canada Inc. N/A 2013-11-04 2019-11-04 Yes 2022-05-04 dinutuximab 212066 Unituxin United Therapeutics Corporation N/A 2018-11-28 2024-11-28 Yes 2027-05-28 dolutegravir sodium 161084 Tivicay ViiV Healthcare ULC TriumeqJulucaDovato 2013-10-31 2019-10-31 Yes 2022-05-01 doravirine 211293 Pifeo Merck Canada Inc. Delstrigo 2018-10-12 2024-10-12 N/A 2026-10-12 dulaglutide 168671 Trulicity Eli Lilly Canada Inc.

N/A 2015-11-10 2021-11-10 N/A 2023-11-10 dupilumab 201285 Dupixent Sanofi-Aventis Canada Inc. N/A 2017-11-30 2023-11-30 Yes 2026-05-30 durvalumab 202953 Imfinzi AstraZeneca Canada Inc. N/A 2017-11-03 2023-11-03 N/A 2025-11-03 edaravone 214391 Radicava Mitsubishi Tanabe Pharma Corporation N/A 2018-10-03 2024-10-03 N/A 2026-10-03 edoxaban 187363 Lixiana Servier Canada Inc.

N/A 2016-11-04 2022-11-04 N/A 2024-11-04 elagolix 209513 Orilissa AbbVie Corporation N/A 2018-10-05 2024-10-05 N/A 2026-10-05 elasomeran 252733 Spikevax ModernaTX, Inc. N/A 2021-09-16 2027-09-16 Yes 2030-03-16 elexacaftor 246955 Trikafta Vertex Pharmaceuticals (Canada) Incorporated N/A 2021-06-18 2027-06-18 Yes 2029-12-18 eliglustat tartrate 183050 Cerdelga Genzyme Canada, A division of Sanofi-aventis Canada Inc. N/A 2017-04-21 2023-04-21 N/A 2025-04-21 elosulfase alfa 170340 Vimizim Biomarin International Limited N/A 2014-07-02 2020-07-02 Yes 2023-01-02 elotuzumab 188144 Empliciti Bristol-Myers Squibb Canada N/A 2016-06-21 2022-06-21 N/A 2024-06-21 eluxadoline 190162 Viberzi Allergan inc.

N/A 2017-01-26 2023-01-26 N/A 2025-01-26 emicizumab 212635 Hemlibra Hoffmann-La Roche Limited N/A 2018-08-02 2024-08-02 Yes 2027-02-02 empagliflozin 162552 Jardiance Boehringer Ingelheim (Canada) Ltd. SynjardyGlyxambi 2015-07-23 2021-07-23 N/A 2023-07-23 enasidenib mesylate 217033 Idhifa Celgene Inc. N/A 2019-02-06 2025-02-06 N/A 2027-02-06 encorafenib 237413 Braftovi Pfizer Canada ULC N/A 2021-03-02 2027-03-02 N/A 2029-03-02 enfortumab vedotin 251438 Padcev Seagen Inc.

N/A 2021-10-29 2027-10-29 N/A 2029-10-29 entrectinib 227517 Rozlytrek Hoffmann-La Roche Limited N/A 2020-02-10 2026-02-10 Yes 2028-08-10 eptinezumab 233288 Vyepti Lundbeck Canada Inc. N/A 2021-01-11 2027-01-11 N/A 2029-01-11 erdafitinib 224529 Balversa Janssen Inc. N/A 2019-10-25 2025-10-25 N/A 2027-10-25 erenumab 208607 Aimovig Novartis Pharmaceuticals Canada Inc.

N/A 2018-08-01 2024-08-01 N/A 2026-08-01 ertugliflozin 204724 Steglatro Merck Canada Inc. SteglujanSegluromet 2018-05-09 2024-05-09 N/A 2026-05-09 eslicarbazepine acetate 165665 Aptiom Sunovion Pharmaceuticals Canada Inc. N/A 2014-07-08 2020-07-08 Yes 2023-01-08 estetrol monohydrate 236197 Nextstellis Searchlight Pharma Inc.

N/A 2021-03-05 2027-03-05 N/A 2029-03-05 evolocumab 178234 Repatha Amgen Canada Inc. N/A 2015-09-10 2021-09-10 Yes 2024-03-10 fedratinib (supplied as fedratinib hydrochloride) 229866 Inrebic Celgene Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 ferric derisomaltose 193890 Monoferric Pharmacosmos A/S N/A 2018-06-22 2024-06-22 N/A 2026-06-22 ferric pyrophosphate citrate 239850 Triferic Avnu Rockwell Medical Inc.

N/A 2021-04-22 2027-04-22 Yes 2029-10-22 finafloxacin 172450 Xtoro MerLion Pharmaceuticals GmbH N/A 2016-03-11 2022-03-11 Yes 2024-09-11 flibanserin 189352 Addyi Searchlight Pharma Inc. N/A 2018-02-27 2024-02-27 N/A 2026-02-27 florbetaben (18F) 193105 Neuraceq Isologic Innovative Radiopharmaceuticals Ltd. N/A 2017-02-22 2023-02-22 N/A 2025-02-22 follitropin delta 188743 Rekovelle Ferring Inc.

N/A 2018-03-22 2024-03-22 N/A 2026-03-22 fostamatinib (supplied as fostamatinib disodium) 232078 Tavalisse Medison Pharma Canada Inc. N/A 2020-11-19 2026-11-19 N/A 2028-11-19 fostemsavir (supplied as fostemsavir tromethamine) 250213 Rukobia Viiv Healthcare ULC N/A 2021-10-01 2027-10-01 N/A 2029-10-01 fremanezumab 226828 Ajovy Teva Canada Limited N/A 2020-04-09 2026-04-09 N/A 2028-04-09 gadoterate meglumine 186333 Dotarem Guerbet N/A 2016-11-26 2022-11-26 Yes 2025-05-26 galcanezumab 219521 Emgality Eli Lilly Canada Inc. N/A 2019-07-30 2025-07-30 N/A 2027-07-30 galsulfase 159020 Naglazyme BioMarin Pharmaceutical Inc.

N/A 2013-09-16 2019-09-16 Yes 2022-03-16 gemtuzumab ozogamicin 223091 Mylotarg Pfizer Canada ULC N/A 2019-11-28 2025-11-28 Yes 2028-05-28 gilteritinib fumarate 227918 Xospata Astellas Pharma Canada Inc. N/A 2019-12-23 2025-12-23 N/A 2027-12-23 givosiran (supplied as givosiran sodium) 237194 Givlaari Alnylam Netherlands B.V.. N/A 2020-10-09 2026-10-09 N/A 2028-10-09 glasdegib 225793 Daurismo Pfizer Canada ULC N/A 2020-04-28 2026-04-28 N/A 2028-04-28 glecaprevir, pibrentasvir 202233 Maviret AbbVie Corporation N/A 2017-08-16 2023-08-16 Yes 2026-02-16 glycerol phenylbutyrate 174219 Ravicti Horizon Pharma Ireland Ltd.

N/A 2016-03-18 2022-03-18 Yes 2024-09-18 grazoprevir, elbasvir 185866 Zepatier Merck Canada Inc. N/A 2016-01-19 2022-01-19 N/A 2024-01-19 guanfacine hydrochloride 150741 Intuniv XR Takeda Canada Inc. N/A 2013-07-05 2019-07-05 Yes 2022-01-05 guselkumab 200590 Tremfya Janssen Inc.

N/A 2017-11-10 2023-11-10 N/A 2025-11-10 hemin 212276 Panhematin Recordati Rare Diseases Canada Inc. N/A 2018-07-13 2024-07-13 N/A 2026-07-13 ibrutinib 174029 Imbruvica Janssen Inc. N/A 2014-11-17 2020-11-17 Yes 2023-05-17 icatibant acetate 162918 Firazyr Takeda Canada Inc.

N/A 2014-06-04 2020-06-04 Yes 2022-12-04 icosapent ethyl 227235 Vascepa HLS Therapeutics Inc. N/A 2019-12-30 2025-12-30 N/A 2027-12-30 idarucizumab 182503 Praxbind Boehringer Ingelheim (Canada) Ltd N/A 2016-04-29 2022-04-29 N/A 2024-04-29 idecabtagene vicleucel 244266 Abecma Celgene Inc. N/A 2021-05-26 2027-05-26 N/A 2029-05-26 idelalisib 172652 Zydelig Gilead Sciences Canada Inc.

N/A 2015-03-27 2021-03-27 N/A 2023-03-27 inclisiran sodium 243470 Leqvio Novartis Pharmaceuticals Canada Inc. N/A 2021-07-26 2027-07-26 N/A 2029-07-26 infigratinib (supplied as infigratinib phosphate) 246904 Truseltiq QED Therapeutics, Inc. N/A 2021-09-27 2027-09-27 N/A 2029-09-27 inotersen sodium 214274 Tegsedi Akcea Therapeutics Inc.

N/A 2018-10-03 2024-10-03 N/A 2026-10-03 inotuzumab ozogamicin 204077 Besponsa Pfizer Canada Inc. N/A 2018-03-15 2024-03-15 N/A 2026-03-15 insulin degludec 198124 Tresiba Novo Nordisk Canada Inc. Xultophy 2017-08-25 2023-08-25 Yes 2026-02-25 ioflupane (123I) 201481 Datscan GE Healthcare Canada Inc.

N/A 2017-12-07 2023-12-07 N/A 2025-12-07 isatuximab 229245 Sarclisa Sanofi-Aventis Canada Inc. N/A 2020-04-29 2026-04-29 N/A 2028-04-29 isavuconazole (supplied as isavuconazonium sulfate) 208919 Cresemba Avir Pharma Inc. N/A 2018-12-19 2024-12-19 N/A 2026-12-19 ivabradine hydrochloride 166949 Lancora Servier Canada Inc.

N/A 2016-12-23 2022-12-23 Yes 2025-06-23 ivermectin 172733 Rosiver Galderma Canada Inc. N/A 2015-04-22 2021-04-22 N/A 2023-04-22 ixazomib (supplied as ixazomib citrate) 190498 Ninlaro Takeda Canada Inc. N/A 2016-08-04 2022-08-04 N/A 2024-08-04 ixekizumab 184993 Taltz Eli Lilly Canada Inc.

N/A 2016-05-25 2022-05-25 Yes 2024-11-25 lanadelumab 213920 Takhzyro Takeda Canada Inc. N/A 2018-09-19 2024-09-19 Yes 2027-03-19 larotrectinib (supplied as larotrectinib sulfate) 219998 Vitrakvi Bayer Inc. N/A 2019-07-10 2025-07-10 Yes 2028-01-10 latanoprostene bunod 211732 Vyzulta Bausch &.

Lomb Incorporated N/A 2018-12-27 2024-12-27 N/A 2026-12-27 ledipasvir 173180 Harvoni Gilead Sciences Canada Inc. N/A 2014-10-15 2020-10-15 Yes 2023-04-15 lefamulin acetate 233292 Xenleta Sunovion Pharmaceuticals Canada Inc. N/A 2020-07-10 2026-07-10 N/A 2028-07-10 lemborexant 231286 Dayvigo Eisai Limited N/A 2020-11-04 2026-11-04 N/A 2028-11-04 lenvatinib mesylate 180877 Lenvima Eisai Limited N/A 2015-12-22 2021-12-22 Yes 2024-06-22 letermovir 204165 Prevymis Merck Canada Inc.

N/A 2017-11-01 2023-11-01 N/A 2025-11-01 levomilnacipran hydrochloride 167319 Fetzima Allergan Inc. N/A 2015-05-08 2021-05-08 N/A 2023-05-08 lifitegrast 199810 Xiidra Novartis Pharmaceuticals Canada Inc. N/A 2017-12-22 2023-12-22 N/A 2025-12-22 linaclotide 161056 Constella Forest Laboratories Canada Inc.

N/A 2013-12-02 2019-12-02 N/A 2021-12-02 lixisenatide 193862 Adlyxine Sanofi-aventis Canada Inc. Soliqua 2017-05-25 2023-05-25 N/A 2025-05-25 lomitapide mesylate 160385 Juxtapid Aegerion Pharmaceuticals Canada Ltd. N/A 2014-02-04 2020-02-04 N/A 2022-02-04 lorlatinib 215733 Lorbrena Pfizer Canada ULC N/A 2019-02-22 2025-02-22 N/A 2027-02-22 lubiprostone 179333 Amitiza Sucampo Pharma Americas LLC N/A 2015-10-14 2021-10-14 N/A 2023-10-14 lumacaftor 181715 Orkambi Vertex Pharmaceuticals (Canada) Incorporated N/A 2016-01-26 2022-01-26 Yes 2024-07-26 lurbinectedin 247485 Zepzelca Jazz Pharmaceuticals Ireland Limited N/A 2021-09-29 2027-09-29 N/A 2029-09-29 luspatercept 236441 Reblozyl Celgene Inc.

N/A 2020-09-25 2026-09-25 N/A 2028-09-25 lutetium177 Lu oxodotreotide 217184 Lutathera Advanced Accelerator Applications USA, Inc. N/A 2019-01-09 2025-01-09 N/A 2027-01-09 macitentan 161372 Opsumit Janssen Inc. Opsynvi 2013-11-06 2019-11-06 Yes 2022-05-06 mecasermin 235023 Increlex Ipsen Biopharmaceuticals Canada Inc.

N/A 2020-12-17 2026-12-17 Yes 2029-06-17 mepolizumab 179850 Nucala GlaxoSmithKline Inc. N/A 2015-12-03 2021-12-03 Yes 2024-06-03 midostaurin 201101 Rydapt Novartis Pharmaceuticals Canada Inc. N/A 2017-07-21 2023-07-21 Yes 2026-01-21 mifepristone 160063 Mifegymiso Linepharma International Limited N/A 2015-07-29 2021-07-29 Yes 2024-01-29 migalastat hydrochloride 196956 Galafold Amicus Therapeutics UK LTD N/A 2017-09-05 2023-09-05 N/A 2025-09-05 modified vaccinia viagra (ankara-bavarian nordic) 144762 Imvamune Bavarian Nordic A/S N/A 2013-11-21 2019-11-21 N/A 2021-11-21 naloxegol oxalate 167790 Movantik Knight Therapeutics Inc.

N/A 2015-06-02 2021-06-02 N/A 2023-06-02 necitumumab 193689 Portrazza Eli Lilly Canada Inc. N/A 2017-03-16 2023-03-16 N/A 2025-03-16 neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily A and Neisseria meningitidis serogroup B recombinant lipoprotein 2086 (rLP2086) subfamily B 195550 Trumenba Pfizer Canada Inc. N/A 2017-10-05 2023-10-05 Yes 2026-04-05 neratinib maleate 218224 Nerlynx Knight Therapeutics Inc.

N/A 2019-07-16 2025-07-16 N/A 2027-07-16 netupitant 196495 Akynzeo Elvium Life Sciences N/A 2017-09-28 2023-09-28 N/A 2025-09-28 nintedanib (supplied as nintedanib esilate) 176043 Ofev Boehringer Ingelheim (Canada) Ltd N/A 2015-06-25 2021-06-25 N/A 2023-06-25 niraparib 216792 Zejula GlaxoSmithKline Inc. N/A 2019-06-27 2025-06-27 N/A 2027-06-27 nivolumab 180828 Opdivo Bristol-Myers-Squibb Canada N/A 2015-09-25 2021-09-25 Yes 2024-03-25 nusinersen 200070 Spinraza Biogen Canada Inc. N/A 2017-06-29 2023-06-29 Yes 2025-12-29 obeticholic acid 198418 Ocaliva Intercept Pharmaceuticals Inc.

N/A 2017-05-24 2023-05-24 N/A 2025-05-24 obiltoxaximab 230825 Anthim Elusys Therapeutics, Inc. N/A 2020-07-30 2026-07-30 N/A 2028-07-30 obinutuzumab 168227 Gazyva Hoffmann-La Roche Limited N/A 2014-11-25 2020-11-25 N/A 2022-11-25 ocrelizumab 198094 Ocrevus Hoffmann-La Roche Limited N/A 2017-08-14 2023-08-14 N/A 2025-08-14 olaparib 182823 Lynparza AstraZeneca Canada Inc. N/A 2016-04-29 2022-04-29 N/A 2024-04-29 olaratumab 203478 Lartruvo Eli Lilly Canada Inc.

N/A 2017-11-23 2023-11-23 N/A 2025-11-23 ombitasvir, paritaprevir, dasabuvir sodium 174739 Holkira Pak Abbvie Corporation Technivie 2014-12-22 2020-12-22 N/A 2022-12-22 onasemnogene abeparvovec 239719 Zolgensma Novartis Pharmaceuticals Canada Inc. N/A 2020-12-15 2026-12-15 Yes 2029-06-15 osimertinib mesylate 188171 Tagrisso AstraZeneca Canada Inc. N/A 2016-07-05 2022-07-05 N/A 2024-07-05 ospemifene 222001 Osphena Duchesnay Inc.

N/A 2021-07-16 2027-07-16 N/A 2029-07-16 ozanimod (supplied as ozanimod hydrochloride) 232761 Zeposia Celgene Inc. N/A 2020-10-02 2026-10-02 N/A 2028-10-02 ozenoxacin 192925 Ozanex Ferrer Internacional, S.A. N/A 2017-05-01 2023-05-01 Yes 2025-11-01 palbociclib 182048 Ibrance Pfizer Canada Inc.

N/A 2016-03-16 2022-03-16 Yes 2024-09-16 patiromer sorbitex calcium 210368 Veltassa Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-10-03 2024-10-03 N/A 2026-10-03 patisiran (as patisiran sodium) 221896 Onpattro Alnylam Netherlands B.V. N/A 2019-06-07 2025-06-07 N/A 2027-06-07 peginterferon beta-1a 166974 Plegridy Biogen Idec Canada Inc.

N/A 2015-08-10 2021-08-10 N/A 2023-08-10 pembrolizumab 175884 Keytruda Merck Canada Inc. N/A 2015-05-19 2021-05-19 Yes 2023-11-19 pemigatinib 242569 Pemazyre Incyte Corporation N/A 2021-09-17 2027-09-17 N/A 2029-09-17 peramivir 191280 Rapivab BioCryst Pharmaceuticals Inc. N/A 2017-01-05 2023-01-05 N/A 2025-01-05 pitolisant hydrochloride 238175 Wakik Endo Ventures Ltd.

N/A 2021-05-25 2027-05-25 N/A 2029-05-25 plecanatide 215288 Trulance Bausch Health, Canada Inc. N/A 2019-10-10 2025-10-10 N/A 2027-10-10 polatuzumab vedotin 232303 Polivy Hoffmann-La Roche Limited N/A 2020-07-09 2026-07-09 N/A 2028-07-09 polidocanol 177359 Varithena Provensis Ltd. N/A 2015-08-04 2021-08-04 N/A 2023-08-04 pomalidomide 165891 Pomalyst Celgene Inc.

N/A 2014-01-20 2020-01-20 Yes 2022-07-20 pralatrexate 207545 Folotyn Servier Canada Inc. N/A 2018-10-26 2024-10-26 N/A 2026-10-26 pralsetinib 243731 Gavreto Hoffmann-La Roche Limited N/A 2021-06-30 2027-06-30 N/A 2029-06-30 prasterone 198822 Intrarosa Endoceutics Inc. N/A 2019-11-01 2025-11-01 N/A 2027-11-01 ponatinib hydrochloride 165121 Iclusig Ariad Pharmaceuticals Inc.

N/A 2015-04-02 2021-04-02 N/A 2023-04-02 ponesimod 239537 Ponvory Janssen Inc. N/A 2021-04-28 2027-04-28 N/A 2029-04-28 propiverine hydrochloride 188323 Mictoryl / Mictoryl Pediatric Duchesnay Inc. N/A 2017-01-05 2023-01-05 Yes 2025-07-05 radium - 223 dichloride 161312 Xofigo Bayer Inc.

N/A 2013-12-12 2019-12-12 N/A 2021-12-12 ramucirumab 176810 Cyramza Eli Lilly Canada Inc. N/A 2015-07-16 2021-07-16 N/A 2023-07-16 ravulizumab 217955 Ultomiris Alexion Pharma GmbH N/A 2019-08-28 2025-08-28 N/A 2027-08-28 recombinant haemagglutinin protein-strain A (H1N1) recombinant haemagglutinin protein-strain A (H3N2) recombinant haemagglutinin protein-strain B (Victoria) recombinant haemagglutinin protein-strain B (Yamagata) 235672 Supemtek Sanofi Pasteur Limited N/A 2021-01-14 2027-01-14 N/A 2029-01-14 recombinant human papillomaviagra types 31, 33, 45, 52 and 58 170006 Gardasil 9 Merck Canada Inc. N/A 2015-02-05 2021-02-05 Yes 2023-08-05 recombinant neisseria meningitidis group B NHBA fusion protein, recombinant neisseria meningitidis group B NadA protein, recombinant neisseria meningitidis group B FHBP fusion protein, outer membrane vesicle (neisseria meningitidis group B NZ98/254 strain) 147275 Bexsero GlaxoSmithKline Inc.

N/A 2013-12-06 2019-12-06 Yes 2022-06-06 recombinant porcine factor VIII (antihemophilic factor (recombinant), porcine sequence) 177290 Obizur Takeda Canada Inc. N/A 2015-10-14 2021-10-14 N/A 2023-10-14 remdesivir 240551 Veklury Gilead Sciences Canada, Inc. N/A 2020-07-27 2026-07-27 N/A 2028-07-27 reslizumab 185873 Cinqair Teva Canada Limited N/A 2016-07-20 2022-07-20 Yes 2025-01-20 ribociclib (supplied as ribociclib succinate) 203884 Kisqali Novartis Pharmaceuticals Canada Inc.

N/A 2018-03-02 2024-03-02 N/A 2026-03-02 ripretinib 234688 Qinlock Deciphera Pharmaceuticals, LLC N/A 2020-06-19 2026-06-19 N/A 2028-06-19 risankizumab 215753 Skyrizi AbbVie Corporation N/A 2019-04-17 2025-04-17 N/A 2027-04-17 risdiplam 242373 Evrysdi Hoffman-La Roche Limited N/A 2021-04-14 2027-04-14 Yes 2029-10-14 romosozumab 197713 Evenity Amgen Canada Inc. N/A 2019-06-17 2025-06-17 N/A 2027-06-17 rupatadine (supplied as rupatadine fumarate) 186488 Rupall Medexus Pharmaceuticals Inc. N/A 2016-07-20 2022-07-20 Yes 2025-01-20 sacituzumab govitecan 248753 Trodelvy Gilead Sciences Canada, Inc.

N/A 2021-09-24 2027-09-24 N/A 2029-09-24 sacubitril 182734 Entresto Novartis Pharmaceuticals Canada Inc. N/A 2015-10-02 2021-10-02 Yes 2024-04-02 safinamide (as safinamide mesylate) 207115 Onstryv Valeo Pharma Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 sarilumab 191745 Kevzara Sanofi-aventis Canada Inc.

N/A 2017-01-12 2023-01-12 N/A 2025-01-12 satralizumab 233642 Enspryng Hoffmann-La Roche Limited N/A 2020-06-01 2026-06-01 Yes 2028-12-01 sebelipase alfa 204085 Kanuma Alexion Pharma GmbH N/A 2017-12-15 2023-12-15 Yes 2026-06-15 secukinumab 170732 Cosentyx Novartis Pharmaceuticals Canada Inc. N/A 2015-02-27 2021-02-27 Yes 2023-08-27 selexipag 182114 Uptravi Janssen Inc. N/A 2016-01-20 2022-01-20 Yes 2024-07-20 selpercatinib 243748 Retevmo Loxo Oncology Inc.

N/A 2021-06-15 2027-06-15 Yes 2029-12-15 semaglutide 202059 Ozempic Novo Nordisk Canada Inc. Rybelsus 2018-01-04 2024-01-04 N/A 2026-01-04 siltuximab 174291 Sylvant EUSA Pharma (UK) Limited N/A 2014-12-03 2020-12-03 N/A 2022-12-03 siponimod 223225 Mayzent Novartis Pharmaceuticals Canada Inc. N/A 2020-02-20 2026-02-20 N/A 2028-02-20 sodium zirconium cyclosilicate 218799 Lokelma AstraZeneca Canada Inc.

N/A 2019-07-25 2025-07-25 N/A 2027-07-25 sofosbuvir 165043 Sovaldi Gilead Sciences Canada Inc. HarvoniEpclusaVosevi 2013-12-13 2019-12-13 N/A 2021-12-13 solriamfetol hydrochloride 237511 Sunosi Jazz Pharmaceuticals Ireland Ltd. N/A 2021-05-13 2027-05-13 N/A 2029-11-13 somatrogon 246729 Ngenla Pfizer Canada ULC N/A 2021-10-26 2027-10-26 Yes 2030-04-26 sonidegib phosphate 229407 Odomzo Sun Pharma Global FZE N/A 2020-06-12 2026-06-12 N/A 2028-06-12 sotorasib 248435 Lumakras Amgen Canada Inc.

N/A 2021-09-10 2027-09-10 N/A 2029-09-10 sucroferric oxyhydroxide 201492 Velphoro Vifor Fresenius Medical Care Renal Pharma Ltd. N/A 2018-01-05 2024-01-05 N/A 2026-01-05 sugammadex sodium 180385 Bridion Merck Canada Inc. N/A 2016-02-05 2022-02-05 Yes 2024-08-05 suvorexant 196367 Belsomra Merck Canada Inc.

N/A 2018-11-29 2024-11-29 N/A 2026-11-29 tafamidis meglumine 228368 Vyndaqel Pfizer Canada ULC Vyndamax 2020-01-20 2026-01-20 N/A 2028-01-20 tafasitamab 247025 Minjuvi Incyte Corporation N/A 2021-08-19 2027-08-19 N/A 2029-08-19 tafluprost 165596 Saflutan Purdue Pharma N/A 2014-05-26 2020-05-26 N/A 2022-05-26 talazoparib (supplied as talazoparib tosylate) 220584 Talzenna Pfizer Canada ULC N/A 2019-09-06 2025-09-06 N/A 2027-09-06 taliglucerase alfa 140854 Elelyso Pfizer Canada Inc. N/A 2014-05-29 2020-05-29 Yes 2022-11-29 tedizolid phosphate 173603 Sivextro Merck Canada Inc. N/A 2015-03-17 2021-03-17 N/A 2023-03-17 teduglutide 180223 Revestive Takeda Canada Inc.

N/A 2015-09-04 2021-09-04 Yes 2024-03-04 telotristat ethyl (as telotristat etiprate) 208730 Xermelo Ipsen Biopharmaceuticals Canada Inc. N/A 2018-10-10 2024-10-10 N/A 2026-10-10 tenapanor hydrochloride 224850 Ibsrela Knight Therapeutics Inc. N/A 2020-04-15 2026-04-15 N/A 2028-04-15 tenofovir alafenamide hemifumarate 181399 Genvoya Gilead Sciences Canada Inc.

DescovyOdefseyVemlidySymtuzaBiktarvy 2015-11-27 2021-11-27 Yes 2024-05-27 tepotinib (supplied as tepotinib hydrochloride) 242300 Tepmetko EMD Serono, a Division of EMD Inc., Canada N/A 2021-05-27 2027-05-27 N/A 2029-05-27 teriflunomide 160646 Aubagio Genzyme Canada a division of Sanofi-aventis Canada Inc. N/A 2013-11-14 2019-11-14 Yes 2022-05-14 tesamorelin 131836 Egrifta Theratechnologies Inc. N/A 2014-04-29 2020-04-29 N/A 2022-04-29 tezacaftor 211292 Symdeko Vertex Pharmaceuticals (Canada) Incorporated N/A 2018-06-27 2024-06-27 Yes 2026-12-27 tildrakizumab 224036 Ilumya Sun Pharma Global FZE N/A 2021-05-19 2027-05-19 N/A 2029-05-19 tisagenlecleucel 213547 / 213698 Kymriah Novartis Pharmaceuticals Canada Inc.

N/A 2018-09-05 2024-09-05 Yes 2027-03-05 tofacitinib 154642 Xeljanz Pfizer Canada Inc. N/A 2014-04-17 2020-04-17 Yes 2022-10-17 tozinameran 252736 Comirnaty BioNTech Manufacturing GmbH N/A 2021-09-16 2027-09-16 Yes 2030-03-16 tralokinumab 245877 Adtralza LEO Pharma Inc. N/A 2021-10-13 2027-10-13 N/A 2029-10-13 trastuzumab deruxtecan 242104 Enhertu AstraZeneca Canada Inc.

N/A 2021-04-15 2027-04-15 N/A 2029-04-15 trifarotene 221945 Aklief Galderma Canada Inc. N/A 2019-11-25 2025-11-25 Yes 2028-05-25 tipiracil hydrochloride 205852 Lonsurf Taiho Pharma Canada Inc. N/A 2018-01-25 2024-01-25 N/A 2026-01-25 triheptanoin 242196 Dojolvi Uagenyx Pharmaceutical Inc.

N/A 2021-02-15 2027-02-15 Yes 2029-08-15 tucatinib 235295 Tukysa Seagen Inc. N/A 2020-06-05 2026-06-05 N/A 2028-06-05 turoctocog alfa 170796 Zonovate Novo Nordisk Canada Inc. N/A 2014-12-08 2020-12-08 Yes 2023-06-08 umeclidinium bromide 161585 Anoro Ellipta GlaxoSmithKline Inc.

Incruse Ellipta 2013-12-23 2019-12-23 N/A 2021-12-23 upadacitinib 223734 Rinvoq AbbVie Corporation N/A 2019-12-23 2025-12-23 Yes 2028-06-23 varicella-zoster viagra glycoprotein E (gE) 200244 Shingrix GlaxoSmithKline Inc. N/A 2017-10-13 2023-10-13 N/A 2025-10-13 vedolizumab 169414 Entyvio Takeda Canada Inc. N/A 2015-01-29 2021-01-29 Yes 2023-07-29 velpatasvir 190521 Epclusa Gilead Sciences Canada Inc.

Vosevi 2016-07-11 2022-07-11 Yes 2025-01-11 venetoclax 190761 Venclexta AbbVie Corporation N/A 2016-09-30 2022-09-30 N/A 2024-09-30 vernakalant hydrochloride 190817 Brinavess Cipher Pharmaceuticals Inc. N/A 2017-03-13 2023-03-13 N/A 2025-03-13 vilanterol trifenatate 157301 Breo Ellipta GlaxoSmithKline Inc. Anoro ElliptaTrelegy Ellipta 2013-07-03 2019-07-03 Yes 2022-01-03 vilazodone hydrochloride 176820 Viibryd Allergan Inc.

N/A 2015-07-16 2021-07-16 Yes 2024-01-16 von willebrand factor (recombinant) (vonicog alfa) 213188 Vonvendi Takeda Canada Inc. N/A 2019-01-10 2025-01-10 N/A 2027-01-10 vorapaxar sulfate 179320 Zontivity Toprol Acquisition LLC N/A 2016-05-13 2022-05-13 N/A 2024-05-13 voretigene neparvovec 233097 Luxturna Novartis Pharmaceuticals Canada Inc. N/A 2020-10-13 2026-10-13 Yes 2029-04-13 vortioxetine hydrobromide 159019 Trintellix Lundbeck Canada Inc.

N/A 2014-10-22 2020-10-22 Yes 2023-04-22 voxilaprevir 202324 Vosevi Gilead Sciences Canada Inc. N/A 2017-08-16 2023-08-16 N/A 2025-08-16 zanubrutinib 242748 Brukinsa BeiGene Switzerland GmbH N/A 2021-03-01 2027-03-01 N/A 2029-03-01.

What is Viagra?

Generic Viagra is used to treat male Impotence also known as Erectile Dysfunction. Also, it has been approved by US FDA for treating pulmonary arterial hypertension.

Strongest viagra pill

A woman strongest viagra pill looks at the "Naming the Lost Memorials," as click here to read the U.S. Deaths from the strongest viagra pill erectile dysfunction disease (erectile dysfunction treatment) are expected to surpass 600,000, at The Green-Wood Cemetery in Brooklyn, New York, U.S., June 10, 2021.Brendan McDermid | ReutersThe U.S. Hit another grim milestone in the viagra Tuesday, reaching more than 600,000 erectile dysfunction treatment fatalities as the nation races to administer at least one treatment strongest viagra pill shot to 70% of adult Americans by the Fourth of July.Deaths in the U.S. Have been slowing for months, according to Johns Hopkins University data, due largely to an aggressive campaign to vaccinate the nation's elderly and strongest viagra pill medically vulnerable people who are most at risk of dying from erectile dysfunction treatment.

About 76% of Americans 65 and older, the group that accounted for a majority of viagra deaths, have been fully vaccinated, according to the Centers for Disease Control and Prevention.Healthcare personnel perform CPR on a patient inside a erectile dysfunction disease (erectile dysfunction treatment) unit at United Memorial Medical Center as the United States nears 300,000 erectile dysfunction treatment deaths, in Houston, Texas, U.S., December 12, 2020. Picture taken December 12, 2020.Callaghan O'Hare | Reuterserectile dysfunction treatment deaths in the U.S., which peaked in January at a daily average of more than 3,000 fatalities, have fallen to a daily average of about strongest viagra pill 360 as of Sunday, according to a seven-day average based on data compiled by Johns Hopkins University. Deaths have gradually declined as strongest viagra pill vaccination rates increased.erectile dysfunction treatments by Pfizer-BioNTech and Moderna were authorized by the Food and Drug Administration for emergency use in December, followed Johnson &. Johnson's in strongest viagra pill February.CNBC Health &.

Science The Pfizer and Moderna treatments, which have been administered to almost 300 million people, have demonstrated more than 90% efficacy against the strongest viagra pill original "wild type" erectile dysfunction treatment strain. Studies have shown that he treatments are still effective against some of the new variants that have emerged over the last year, including the the delta variant first identified in India, but less so.Johnson &. Johnson has administered about 9 strongest viagra pill million doses of its one-shot treatment in the U.S. The company's shot was paused for 10 days in April by the FDA after reports of rare blood clots emerged in several strongest viagra pill patients.The U.S.

Has recorded more strongest viagra pill erectile dysfunction treatment cases than any other country in the world — about 33.5 million cases, according to data compiled by John Hopkins University. Globally, there have been more than 176 million cases recorded, and more than 3.8 million deaths.With new variants emerging that are more transmissible and could potentially lead to more severe illness, federal strongest viagra pill health officials have pushed young adults to get their treatments as well. Pfizer's erectile dysfunction treatment was given emergency approval for buy viagra without a prescription adolescents last month.President Joe Biden, his wife Jill Biden, U.S. Vice President Kamala Harris and Second Gentleman Doug Emhoff attend a moment of silence strongest viagra pill and candle lighting ceremony to commemorate the grim milestone of 500,000 U.S.

Deaths from the erectile dysfunction disease (erectile dysfunction treatment) at the White House in Washington, U.S., February 22, 2021.Jonathan Ernst | ReutersThe impact of the viagra strongest viagra pill was felt deeply across the U.S. The national unemployment rate soared to 14.8% strongest viagra pill in April 2020, the highest since data collection began in 1948, as states across the nation instituted lockdowns to control the outbreak, according to the Congressional Research Service.Black, Hispanic and young workers were disproportionately impacted by the lockdowns. Throughout the viagra, Black workers experienced a strongest viagra pill peak unemployment rate of 16.7%, while Hispanic workers experienced a peak unemployment rate of 18.5%. For white workers, the number hit a peak of 14.1%.

As of May 2021, strongest viagra pill unemployment rates for Black and Hispanic workers are still higher than those for white workers.In Feb. 2020, before most lockdowns occurred, the unemployment rate in the strongest viagra pill U.S. Was 3.5% strongest viagra pill. Unemployment has strongest viagra pill improved, but is still stubbornly high compared with recent years, hovering at 5.8% in May.Currently, more than half of the U.S.

Population, 174.2 million people, have received at least one shot of a erectile dysfunction treatment and about 44% of the population is fully vaccinated, according to the Centers for Disease Control and Prevention.More than 64% of adults in the U.S. Have received at least one treatment dose, inching closer to an optimistic goal of having 70% strongest viagra pill of all adults in the country at least partially immunized by Fourth of July.Correction. This story strongest viagra pill was updated to correct the day the U.S. Surpassed 600,000 strongest viagra pill fatalities.

A woman looks at buy generic viagra online the viagra cost "Naming the Lost Memorials," as the U.S. Deaths from the erectile dysfunction viagra cost disease (erectile dysfunction treatment) are expected to surpass 600,000, at The Green-Wood Cemetery in Brooklyn, New York, U.S., June 10, 2021.Brendan McDermid | ReutersThe U.S. Hit another grim milestone in the viagra Tuesday, reaching more than 600,000 erectile dysfunction treatment fatalities as the nation viagra cost races to administer at least one treatment shot to 70% of adult Americans by the Fourth of July.Deaths in the U.S.

Have been slowing for months, according to Johns Hopkins University data, due largely to viagra cost an aggressive campaign to vaccinate the nation's elderly and medically vulnerable people who are most at risk of dying from erectile dysfunction treatment. About 76% of Americans 65 and older, the group that accounted for a majority of viagra deaths, have been fully vaccinated, according to the Centers for Disease Control and Prevention.Healthcare personnel perform CPR on a patient inside a erectile dysfunction disease (erectile dysfunction treatment) unit at United Memorial Medical Center as the United States nears 300,000 erectile dysfunction treatment deaths, in Houston, Texas, U.S., December 12, 2020. Picture taken December 12, 2020.Callaghan O'Hare | Reuterserectile dysfunction treatment deaths in the U.S., which peaked in January at a daily average of more than 3,000 fatalities, have fallen to a daily average of about 360 as of Sunday, according to a seven-day average based on data compiled by Johns Hopkins viagra cost University.

Deaths have gradually declined as vaccination rates increased.erectile dysfunction treatments viagra cost by Pfizer-BioNTech and Moderna were authorized by the Food and Drug Administration for emergency use in December, followed Johnson &. Johnson's in February.CNBC Health viagra cost &. Science The Pfizer and Moderna treatments, which have been administered to almost 300 million people, have demonstrated more than 90% efficacy against viagra cost the original "wild type" erectile dysfunction treatment strain.

Studies have shown that he treatments are still effective against some of the new variants that have emerged over the last year, including the the delta variant first identified in India, but less so.Johnson &. Johnson has administered about 9 million doses viagra cost of its one-shot treatment in the U.S. The company's shot was paused for 10 days in April by the FDA after reports of rare viagra cost blood clots emerged in several patients.The U.S.

Has recorded viagra cost more erectile dysfunction treatment cases than any other country in the world — about 33.5 million cases, according to data compiled by John Hopkins University. Globally, there have been more than 176 million cases recorded, and more than 3.8 million deaths.With new variants emerging that are more transmissible and could potentially lead to more severe illness, federal health officials have pushed young adults to get their treatments as viagra cost well. Pfizer's erectile dysfunction treatment was given emergency approval for adolescents last month.President Joe Biden, his wife Jill Biden, U.S.

Vice President Kamala Harris and Second Gentleman Doug Emhoff attend a moment of silence and candle lighting ceremony to commemorate the grim milestone of 500,000 U.S viagra cost. Deaths from the erectile dysfunction disease (erectile dysfunction treatment) at the White House in Washington, U.S., February 22, 2021.Jonathan Ernst | ReutersThe impact of viagra cost the viagra was felt deeply across the U.S. The national unemployment rate soared to 14.8% in April 2020, the highest since data collection began in 1948, as states across the nation instituted lockdowns to control the outbreak, according to viagra cost the Congressional Research Service.Black, Hispanic and young workers were disproportionately impacted by the lockdowns.

Throughout the viagra, viagra cost Black workers experienced a peak unemployment rate of 16.7%, while Hispanic workers experienced a peak unemployment rate of 18.5%. For white workers, the number hit a peak of 14.1%. As of May viagra cost 2021, unemployment rates for Black and Hispanic workers are still higher than those for white workers.In Feb.

2020, before most lockdowns occurred, the unemployment rate viagra cost in the U.S. Was 3.5% viagra cost. Unemployment has improved, but is still stubbornly high compared with recent years, hovering at 5.8% in May.Currently, more than half viagra cost of the U.S.

Population, 174.2 million people, have received at least one shot of a erectile dysfunction treatment and about 44% of the population is fully vaccinated, according to the Centers for Disease Control and Prevention.More than 64% of adults in the U.S. Have received at least one treatment dose, inching closer to an optimistic goal of having 70% of all viagra cost adults in the country at least partially immunized by Fourth of July.Correction. This story was updated to viagra cost correct the day the U.S.

Surpassed 600,000 fatalities viagra cost. It was Tuesday..

Does viagra really work

By Robert does viagra really work Lasix 100mg price Preidt HealthDay Reporter FRIDAY, Oct. 16, 2020 (HealthDay News) -- If you're pregnant and you think popping nonsteroidal anti-inflammatory drugs (NSAIDs) for your aches and pains is safe, think again. The U.S does viagra really work. Food and Drug Administration warned on Thursday that taking these widely used painkillers -- which include Advil, Motrin, Aleve and Celebrex -- at 20 weeks or later in a pregnancy could raise the risk of complications. Specifically, taking the medications can cause rare but serious kidney problems in the unborn baby that can lead to low levels of amniotic fluid, increasing the potential for pregnancy complications.

After about 20 weeks of pregnancy, the fetus's kidneys begin producing most of does viagra really work the amniotic fluid, so kidney problems can cause low levels of this protective fluid. Low levels of amniotic fluid usually resolve if a pregnant woman stops taking an NSAID, according to the FDA. The agency said it has ordered that NSAID labeling warns women and their health care providers about this risk. NSAIDs are prescription and over-the-counter (OTC) drugs that include ibuprofen, naproxen, diclofenac does viagra really work and celecoxib, which are taken to treat pain and fever. Aspirin is also an NSAID, but the new labeling rules don't apply to the use of low-dose aspirin.

"It is important that women understand the benefits and risks of the medications they may take over the course of their pregnancy," Dr. Patrizia Cavazzoni, acting director of FDA's Center for Drug Evaluation and Research, said does viagra really work in an agency news release. One ob-gyn noted that over-the-counter NSAIDs may pose the greatest danger to pregnant women. "Many female patients use ibuprofen regularly for headaches and menstrual cramps," said does viagra really work Dr. Jennifer Wu, from Lenox Hill Hospital in New York City.

"It is very important that these patients realize that ibuprofen and other NSAIDs pose a unique danger to pregnant patients. "The majority of patients get these medications over the counter and may even be using does viagra really work them at the prescription-strength level," Wu added. "While many prescription drugs come with the oversight of the pharmacist and a warning label, the over-the-counter medications lack all this. Patients also often assume that over-the-counter necessarily means safe." Continued The FDA's warning comes after a review of medical literature and cases reported to the agency about low amniotic fluid levels or kidney problems in unborn babies associated with NSAID use during pregnancy. For prescription NSAIDs, the new FDA warning recommends limiting use between does viagra really work about 20 weeks to 30 weeks of pregnancy.

A warning to avoid taking NSAIDs after about 30 weeks of pregnancy was already included in prescribing information due to a risk of heart problems in unborn babies. If a health care provider believes NSAIDs are necessary between about 20 and 30 weeks of pregnancy, use should be limited to the lowest possible dose and shortest possible length of time, the FDA said. Makers of OTC NSAIDs does viagra really work intended for adults will also make similar updates to their labeling, according to the agency. WebMD News from HealthDay Copyright © 2013-2020 HealthDay. All rights reserved..

By Robert Preidt HealthDay Reporter Lasix 100mg price FRIDAY, viagra cost Oct. 16, 2020 (HealthDay News) -- If you're pregnant and you think popping nonsteroidal anti-inflammatory drugs (NSAIDs) for your aches and pains is safe, think again. The U.S viagra cost. Food and Drug Administration warned on Thursday that taking these widely used painkillers -- which include Advil, Motrin, Aleve and Celebrex -- at 20 weeks or later in a pregnancy could raise the risk of complications.

Specifically, taking the medications can cause rare but serious kidney problems in the unborn baby that can lead to low levels of amniotic fluid, increasing the potential for pregnancy complications. After about 20 weeks of pregnancy, the fetus's kidneys begin producing most of the amniotic fluid, so kidney problems can viagra cost cause low levels of this protective fluid. Low levels of amniotic fluid usually resolve if a pregnant woman stops taking an NSAID, according to the FDA. The agency said it has ordered that NSAID labeling warns women and their health care providers about this risk.

NSAIDs are prescription and over-the-counter (OTC) drugs that include ibuprofen, naproxen, diclofenac and celecoxib, which are taken to viagra cost treat pain and fever. Aspirin is also an NSAID, but the new labeling rules don't apply to the use of low-dose aspirin. "It is important that women understand the benefits and risks of the medications they may take over the course of their pregnancy," Dr. Patrizia Cavazzoni, acting director of FDA's Center for Drug Evaluation and Research, said in viagra cost an agency news release.

One ob-gyn noted that over-the-counter NSAIDs may pose the greatest danger to pregnant women. "Many female patients use ibuprofen regularly for headaches and menstrual cramps," said viagra cost Dr. Jennifer Wu, from Lenox Hill Hospital in New York City. "It is very important that these patients realize that ibuprofen and other NSAIDs pose a unique danger to pregnant patients.

"The majority of patients get these medications over the counter and may even be using them at viagra cost the prescription-strength level," Wu added. "While many prescription drugs come with the oversight of the pharmacist and a warning label, the over-the-counter medications lack all this. Patients also often assume that over-the-counter necessarily means safe." Continued The FDA's warning comes after a review of medical literature and cases reported to the agency about low amniotic fluid levels or kidney problems in unborn babies associated with NSAID use during pregnancy. For prescription NSAIDs, the new FDA warning recommends limiting use between about 20 weeks to 30 weeks of pregnancy viagra cost.

A warning to avoid taking NSAIDs after about 30 weeks of pregnancy was already included in prescribing information due to a risk of heart problems in unborn babies. If a health care provider believes NSAIDs are necessary between about 20 and 30 weeks of pregnancy, use should be limited to the lowest possible dose and shortest possible length of time, the FDA said. Makers of OTC NSAIDs intended for adults will also make similar updates to their labeling, according to the viagra cost agency. WebMD News from HealthDay Copyright © 2013-2020 HealthDay.

Long term side effects of viagra

Notice click to find out more long term side effects of viagra. The Secretary of Health and Human Services announces a meeting of the Interdepartmental Serious Mental Illness Coordinating Committee (ISMICC). The ISMICC is open to the public and members of the public can attend the meeting via telephone or webcast only, and not in person. Agenda with long term side effects of viagra call-in information will be posted on SAMHSA's website prior to the meeting at.

Https://www.samhsa.gov/​about-us/​advisory-councils/​meetings. The meeting will include information on federal efforts related to serious mental illness (SMI) and serious emotional disturbance (SED). September 29, 2020, 1:00 p.m.—TBD (ET)/Open long term side effects of viagra. The meeting will be held at SAMHSA Headquarters, 5600 Fishers Lane, Rockville, Maryland 20857, Pavilions A and B.

The meeting can be accessed via webcast at. Https://protect2.fireeye.com/​url?. €‹k=​766a2ec8-2a3f2718-766a1ff7-0cc47a6a52de-658aca2b78455d15&​u=​ https://www.mymeetings.com/​nc/​join.php?. €‹i=​PWXW1647116&​p=​4987834&​t=​c or by joining the teleconference at the toll-free, dial-in number at 877-950-3592.

Passcode 4987834. Start Further Info Pamela Foote, ISMICC Designated Federal Officer, SAMHSA, 5600 Fishers Lane, 14E53C, Rockville, MD 20857. Telephone. 240-276-1279.

Email. Pamela.foote@samhsa.hhs.gov. End Further Info End Preamble Start Supplemental Information I. Background and Authority The ISMICC was established on March 15, 2017, in accordance with section 6031 of the 21st Century Cures Act, and the Federal Advisory Committee Act, 5 U.S.C.

App., as amended, to report to the Secretary, Congress, and any other relevant federal department or agency on advances in SMI and SED, research related to the prevention of, diagnosis of, intervention in, and treatment and recovery of SMIs, SEDs, and advances in access to services and supports for adults with SMI or children with SED. In addition, the ISMICC will evaluate the effect federal programs related to SMI and SED have on public health, including public health outcomes such as. (A) Rates of suicide, suicide attempts, incidence and prevalence of SMIs, SEDs, and substance use disorders, overdose, overdose deaths, emergency hospitalizations, emergency room boarding, preventable emergency room visits, interaction with the criminal justice system, homelessness, and unemployment. (B) increased rates of employment and enrollment in educational and vocational programs.

(C) quality of mental and substance use disorders treatment services. Or (D) any other criteria determined by the Secretary. Finally, the ISMICC will make specific recommendations for actions that agencies can take to better coordinate the administration of mental health services for adults with SMI or children with SED. Not later than one (1) year after the date of enactment of the 21st Century Cures Act, and five (5) years after such date of enactment, the ISMICC shall submit a report to Congress and any other relevant federal department or agency.

II. Membership This ISMICC consists of federal members listed below or their designees, and non-federal public members. Federal Membership. Members include, The Secretary of Health and Human Services.

The Assistant Secretary for Mental Health and Substance Use. The Attorney General. The Secretary of the Department of Veterans Affairs. The Secretary of the Department of Defense.

The Secretary of the Department of Housing and Urban Development. The Secretary of the Department of Education. The Secretary of the Department of Labor. The Administrator of the Centers for Medicare and Medicaid Services.

And The Commissioner of the Social Security Administration. Non-Federal Membership. Members include, 14 non-federal public members appointed by the Secretary, representing psychologists, psychiatrists, social workers, peer support specialists, and other providers, patients, family of patients, law enforcement, the judiciary, and leading research, advocacy, or service organizations. The ISMICC is required to meet at least twice per year.

To attend virtually, submit written or brief oral comments, or request special accommodation for persons with disabilities, contact Pamela Foote. Individuals can also register on-line at. Https://snacregister.samhsa.gov/​MeetingList.aspx. The public comment section is scheduled for 2:15 p.m.

Eastern Time (ET), and individuals interested in submitting a comment, must notify Pamela Foote on or before September 18, 2020 via email to. Pamela.Foote@samhsa.hhs.gov. Up to three minutes will be allotted for each approved public comment as time permits. Written comments received in advance of the meeting will be considered for inclusion in the official record of the meeting.

Substantive meeting information and a roster of Committee members is available at the Committee's website. Https://www.samhsa.gov/​about-us/​advisory-councils/​meetings. Start Signature Dated. September 1, 2020.

Notice https://ferienhaus-sticher-borkum.de/how-to-buy-cheap-kamagra-online/ viagra cost. The Secretary of Health and Human Services announces a meeting of the Interdepartmental Serious Mental Illness Coordinating Committee (ISMICC). The ISMICC is open to the public and members of the public can attend the meeting via telephone or webcast only, and not in person. Agenda with call-in information will be posted on SAMHSA's website prior to the meeting viagra cost at.

Https://www.samhsa.gov/​about-us/​advisory-councils/​meetings. The meeting will include information on federal efforts related to serious mental illness (SMI) and serious emotional disturbance (SED). September 29, viagra cost 2020, 1:00 p.m.—TBD (ET)/Open. The meeting will be held at SAMHSA Headquarters, 5600 Fishers Lane, Rockville, Maryland 20857, Pavilions A and B.

The meeting can be accessed via webcast at. Https://protect2.fireeye.com/​url?. €‹k=​766a2ec8-2a3f2718-766a1ff7-0cc47a6a52de-658aca2b78455d15&​u=​ https://www.mymeetings.com/​nc/​join.php?. €‹i=​PWXW1647116&​p=​4987834&​t=​c or by joining the teleconference at the toll-free, dial-in number at 877-950-3592.

Passcode 4987834. Start Further Info Pamela Foote, ISMICC Designated Federal Officer, SAMHSA, 5600 Fishers Lane, 14E53C, Rockville, MD 20857. Telephone. 240-276-1279.

Email. Pamela.foote@samhsa.hhs.gov. End Further Info End Preamble Start Supplemental Information I. Background and Authority The ISMICC was established on March 15, 2017, in accordance with section 6031 of the 21st Century Cures Act, and the Federal Advisory Committee Act, 5 U.S.C.

App., as amended, to report to the Secretary, Congress, and any other relevant federal department or agency on advances in SMI and SED, research related to the prevention of, diagnosis of, intervention in, and treatment and recovery of SMIs, SEDs, and advances in access to services and supports for adults with SMI or children with SED. In addition, the ISMICC will evaluate the effect federal programs related to SMI and SED have on public health, including public health outcomes such as. (A) Rates of suicide, suicide attempts, incidence and prevalence of SMIs, SEDs, and substance use disorders, overdose, overdose deaths, emergency hospitalizations, emergency room boarding, preventable emergency room visits, interaction with the criminal justice system, homelessness, and unemployment. (B) increased rates of employment and enrollment in educational and vocational programs.

(C) quality of mental and substance use disorders treatment services. Or (D) any other criteria determined by the Secretary. Finally, the ISMICC will make specific recommendations for actions that agencies can take to better coordinate the administration of mental health services for adults with SMI or children with SED. Not later than one (1) year after the date of enactment of the 21st Century Cures Act, and five (5) years after such date of enactment, the ISMICC shall submit a report to Congress and any other relevant federal department or agency.

II. Membership This ISMICC consists of federal members listed below or their designees, and non-federal public members. Federal Membership. Members include, The Secretary of Health and Human Services.

The Assistant Secretary for Mental Health and Substance Use. The Attorney General. The Secretary of the Department of Veterans Affairs. The Secretary of the Department of Defense.

The Secretary of the Department of Housing and Urban Development. The Secretary of the Department of Education. The Secretary of the Department of Labor. The Administrator of the Centers for Medicare and Medicaid Services.

And The Commissioner of the Social Security Administration. Non-Federal Membership. Members include, 14 non-federal public members appointed by the Secretary, representing psychologists, psychiatrists, social workers, peer support specialists, and other providers, patients, family of patients, law enforcement, the judiciary, and leading research, advocacy, or service organizations. The ISMICC is required to meet at least twice per year.

To attend virtually, submit written or brief oral comments, or request special accommodation for persons with disabilities, contact Pamela Foote. Individuals can also register on-line at. Https://snacregister.samhsa.gov/​MeetingList.aspx. The public comment section is scheduled for 2:15 p.m.

Eastern Time (ET), and individuals interested in submitting a comment, must notify Pamela Foote on or before September 18, 2020 via email to. Pamela.Foote@samhsa.hhs.gov. Up to three minutes will be allotted for each approved public comment as time permits. Written comments received in advance of the meeting will be considered for inclusion in the official record of the meeting.

Substantive meeting information and a roster of Committee members is available at the Committee's website. Https://www.samhsa.gov/​about-us/​advisory-councils/​meetings. Start Signature Dated. September 1, 2020.

Buy viagra with free samples

Looking over every detail of the human buy viagra with free samples body, male nipples may be the most obviously useless. In females, they are essential for delivering life-sustaining breast milk to newborns. In men, they serve, buy viagra with free samples well, no apparent purpose. Virtually every other anatomical structure clearly furthers the enterprise of survival and reproduction, so why would we evolve one that doesn’t?.

The answer may lie in a subtle misunderstanding of evolutionary theory’s fundamental assumption. That living organisms change over time, becoming better adapted to their environments in response to buy viagra with free samples the pressures of natural selection. Few scientific tenets are as certain as this one. But it’s easy to oversimplify that account and interpret it to mean that every modification in a species is adaptive, developed to fulfill a vital function.This tempting idea goes back as far as Erasmus Darwin, the grandfather of Charles Darwin, who considered adaptivity in his 1794 book Zoonomia.

Or, the Laws of Organic Life, an buy viagra with free samples early treatise on evolution. As far as he could see, all animal traits seem to have evolved toward greater utility, with one exception. €œThe breasts and teats of all male quadrupeds, to which no use can now be assigned.” The Harmless NippleAs evolutionary theory progressed through another Darwin and beyond, buy viagra with free samples biologists refined their understanding of its mechanisms. The evolutionary biologists Stephen Jay Gould and Richard Lewontin, in a highly influential (and provocative) 1979 paper, argued against the “Panglossian paradigm” of adaptation, which claims — like its indomitably optimistic namesake in Voltaire’s Candide — that evolution has crafted “the best of all possible worlds.”Gould and Lewontin contend that other factors besides natural selection control the operation of evolution, one being simply the lack of selective pressure against a trait.

The male nipple doesn’t aid in survival and reproduction, but it doesn’t hinder, either. Why would natural selection do away with a harmless circle buy viagra with free samples of flesh?. In another paper, in 1993, Gould addressed the nipple query specifically. He wrote that of all the evolutionary conundrums for “well-informed nonscientific readers … no single item has evoked more puzzlement than the very issue that Erasmus Darwin chose as a primary challenge to his concept of pervasive utility — male nipples.” To Gould, the solution is straightforward.

It requires “no adaptive explanation at all,” only the realization that evolution deals with more pressing buy viagra with free samples matters than the superficial features of a man’s chest.Embryonic OriginsThere is, of course, a proximate explanation for the persistence of male nipples. In an odd way, Erasmus Darwin nearly glimpsed the truth in his own speculation two and a half centuries ago, when he suggested they were vestiges of an earlier stage of human evolution — a time “during the infancy of the world” when, he thought, all people were hermaphrodites. Males and females do, in buy viagra with free samples fact, start from the same genetic blueprint. Embryos, in their first weeks, develop structures with the potential to become either male or female sex organs.

Only later do sex-specific hormones begin to mold those structures into either a clitoris or a penis, either functioning mammary glands or unproductive male nipples. “Males and females are not separate entities, shaped independently by natural selection,” Gould writes buy viagra with free samples. €œBoth sexes are variants upon a single ground plan, elaborated in later embryology.” Nipples begin to appear before that sex differentiation begins, so males are stuck with them as they mature.It’s not entirely fair to say they serve no possible purpose, though. Under unusual conditions, like starvation or a spike in levels of the hormone prolactin, men can actually produce milk — to answer Robert DeNiro’s unforgettably funny and awkward inquiry in Meet the Parents.

As Pulitzer-prize-winning author Jared Diamond wrote in a 1995 Discover article titled Father’s Milk, “Lactation, then, lies buy viagra with free samples within a male mammal’s physiological reach.”Nipples are also highly sensitive, and research shows that in men as well as women they respond to sexual stimulation. One study found that about half of men (and more than 80 percent of women) report nipple stimulation enhances their sexual arousal. Maybe these minor compensations, rather than a boost in physical and reproductive fitness, justify the male nipple’s existence..

Looking over Amoxil street price every detail of the human body, male nipples viagra cost may be the most obviously useless. In females, they are essential for delivering life-sustaining breast milk to newborns. In men, they serve, well, viagra cost no apparent purpose. Virtually every other anatomical structure clearly furthers the enterprise of survival and reproduction, so why would we evolve one that doesn’t?.

The answer may lie in a subtle misunderstanding of evolutionary theory’s fundamental assumption. That living organisms change over time, becoming better adapted viagra cost to their environments in response to the pressures of natural selection. Few scientific tenets are as certain as this one. But it’s easy to oversimplify that account and interpret it to mean that every modification in a species is adaptive, developed to fulfill a vital function.This tempting idea goes back as far as Erasmus Darwin, the grandfather of Charles Darwin, who considered adaptivity in his 1794 book Zoonomia.

Or, the Laws of Organic Life, an early treatise on viagra cost evolution. As far as he could see, all animal traits seem to have evolved toward greater utility, with one exception. €œThe breasts and teats of all male quadrupeds, to which no use can now be assigned.” The Harmless NippleAs evolutionary theory progressed through viagra cost another Darwin and beyond, biologists refined their understanding of its mechanisms. The evolutionary biologists Stephen Jay Gould and Richard Lewontin, in a highly influential (and provocative) 1979 paper, argued against the “Panglossian paradigm” of adaptation, which claims — like its indomitably optimistic namesake in Voltaire’s Candide — that evolution has crafted “the best of all possible worlds.”Gould and Lewontin contend that other factors besides natural selection control the operation of evolution, one being simply the lack of selective pressure against a trait.

The male nipple doesn’t aid in survival and reproduction, but it doesn’t hinder, either. Why would natural selection do away with a harmless circle viagra cost of flesh?. In another paper, in 1993, Gould addressed the nipple query specifically. He wrote that of all the evolutionary conundrums for “well-informed nonscientific readers … no single item has evoked more puzzlement than the very issue that Erasmus Darwin chose as a primary challenge to his concept of pervasive utility — male nipples.” To Gould, the solution is straightforward.

It requires “no adaptive explanation at all,” only the realization that evolution deals with more pressing matters than the superficial features of a man’s chest.Embryonic OriginsThere viagra cost is, of course, a proximate explanation for the persistence of male nipples. In an odd way, Erasmus Darwin nearly glimpsed the truth in his own speculation two and a half centuries ago, when he suggested they were vestiges of an earlier stage of human evolution — a time “during the infancy of the world” when, he thought, all people were hermaphrodites. Males and females do, in fact, start viagra cost from the same genetic blueprint. Embryos, in their first weeks, develop structures with the potential to become either male or female sex organs.

Only later do sex-specific hormones begin to mold those structures into either a clitoris or a penis, either functioning mammary glands or unproductive male nipples. “Males and females are not separate entities, shaped independently by natural selection,” Gould viagra cost writes. €œBoth sexes are variants upon a single ground plan, elaborated in later embryology.” Nipples begin to appear before that sex differentiation begins, so males are stuck with them as they mature.It’s not entirely fair to say they serve no possible purpose, though. Under unusual conditions, like starvation or a spike in levels of the hormone prolactin, men can actually produce milk — to answer Robert DeNiro’s unforgettably funny and awkward inquiry in Meet the Parents.

As Pulitzer-prize-winning author Jared Diamond wrote in a 1995 Discover article titled Father’s viagra cost Milk, “Lactation, then, lies within a male mammal’s physiological reach.”Nipples are also highly sensitive, and research shows that in men as well as women they respond to sexual stimulation. One study found that about half of men (and more than 80 percent of women) report nipple stimulation enhances their sexual arousal. Maybe these minor compensations, rather than a boost in physical and reproductive fitness, justify the male nipple’s existence..